Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase.
Ayano Fukuhara,Ayano Fukuhara,Hidemitsu Nakajima,Yuya Miyamoto,Yuya Miyamoto,Katsuaki Inoue,Satoshi Kume,Young-Ho Lee,Masanori Noda,Susumu Uchiyama,Shigeru Shimamoto,Shigenori Nishimura,Tadayasu Ohkubo,Yuji Goto,Tadayoshi Takeuchi,Takashi Inui +15 more
TL;DR: The feasibility of a novel drug delivery system (DDS), utilizing L-PGDS, for poorly water-soluble compounds such as diazepam (DZP), a major benzodiazepine anxiolytic drug, and 6-nitro-7-sulfamoylbenzo-2,3-dione (NBQX), an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (
Journal ArticleDOI
Effect of external factors on the curcumin/2-hydroxypropyl-β-cyclodextrin: in vitro and in vivo study
TL;DR: Interestingly, it could be concluded that the degrees of curcumin stability improved by HPβCD grew with increasing drug–cyclodextrin binding ability.
Journal ArticleDOI
Investigation of solvent effect and cyclodextrins on fluorescence properties of ochratoxin A.
Javad Hashemi,Naader Alizadeh +1 more
TL;DR: The fluorescence quenching of OTA by chloroform (aprotic) and water (protic) were studied in methanol as solvent at room temperature and it was inferred that non-linearity can be attributed to fractional accessibility of fluorophore to quencher.
Journal ArticleDOI
Spectrofluorimetric study of eflucimibe-γ-cyclodextrin inclusion complex
TL;DR: In this article, a 1:1 stoichiometric ratio and a 20 M−1 formation constant were obtained for eflucimibe in water containing 10% methanol.
Journal ArticleDOI
Do Cyclodextrins Aggregate in Water? Insights from NMR Experiments.
TL;DR: The question of aggregation of native cyclodextrins (α, β, and γ-) in aqueous solutions is addressed by using (1)H NMR techniques, including NMR diffusometry, relaxometry, and proton peak intensities, and within the detection limit of the NMR experiments, no aggregates ofcyclodextrin were observed.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.