Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Preparation, physicochemical analysis and molecular modeling investigation of 2,2′-Bipyridine: β-Cyclodextrin inclusion complex in solution and solid state
TL;DR: In this paper, 2,2′-Bipyridine (BPY) and β-Cyclodextrin (β-CD) were investigated in solution and solid state using absorption and fluorescence spectroscopy.
Journal ArticleDOI
Effect of Buffer Species on the Complexation of Basic Drug Terfenadine with β-Cyclodextrin
TL;DR: In this article, a phase solubility diagram of terfenadine (Terf) with β-cyclodextrin (β-CD) in solution and solid state has been investigated by using XRPD, differential scanning calorimetry, powder X-ray diffractometry (PXD) and proton nuclear magnetic resonance (1H-NMR).
Journal ArticleDOI
Study of the inclusion of gliclazide in α-cyclodextrin
Journal ArticleDOI
Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake
Duy-Khiet Ho,Ana Costa,Chiara De Rossi,Cristiane de Souza Carvalho-Wodarz,Brigitta Loretz,Claus-Michael Lehr +5 more
TL;DR: The developed sMC is a suitable system with promising perspectives recommended for pulmonary extracellular infection therapeutics, and the subsequent phagocytosis of the carrier may be considered as an efficient pathway for its safe degradation and elimination.
Journal ArticleDOI
Some new DTPA-N,N″-bis(amides) functionalized by alkyl carboxylates: Synthesis, complexation and stability properties
TL;DR: In this paper, a new series of DTPA-N, N-bis(amide) ligands functionalized by alkyl carboxylates on the amide side-arms (1a − 1l ) and their Gd(III) complexes of the type [Gd( 1 )(H 2 O)] were synthesized and characterized by analytical and spectroscopic techniques.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.