Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Cyclodextrins and their uses: a review
TL;DR: Cyclodextrins are a family of cyclic oligosaccharides composed of α-(1,4) linked glucopyranose subunits.
Journal ArticleDOI
Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
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Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.
Journal ArticleDOI
Cyclodextrin-based pharmaceutics: past, present and future
Mark E. Davis,Marcus E. Brewster +1 more
TL;DR: Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
References
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Journal ArticleDOI
Cyclodextrin-adamantanecarboxylate inclusion complexes: studies of the variation in cavity size
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Chemical stability of pharmaceuticals
TL;DR: In this paper, the Chemical Stability of Pharmaceuticals (CSOP) of pharmaceuticals has been studied in terms of the chemical stability of pharmaceutical drugs and their stability in pharmaceuticals.
Journal ArticleDOI
Thermodynamic and Nuclear Magnetic Resonance Study of the Interactions of .alpha.- and .beta.-Cyclodextrin with Model Substances: Phenethylamine, Ephedrines, and Related Substances
Mikhail V. Rekharsky,Robert N. Goldberg,Frederick P. Schwarz,Yadu B. Tewari,Philip D. Ross,Yuko Yamashoji,Yoshihisa Inoue +6 more
Journal ArticleDOI
The effect of water-soluble polymers on drug-cyclodextrin complexation
TL;DR: In aqueous solutions water-soluble polymers were shown to increase the solubilising effect of cyclodextrins on drugs as discussed by the authors, and the polymers increased the stability constants of the drug-cyclodextrin complexes.