Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Optimization of biotransformation from phytosterol to androstenedione by a mutant Mycobacterium neoaurum ZJUVN-08 *
TL;DR: Responsibility surface methodology was a powerful and efficient method to optimize the parameters of PS biotransformation process and showed that molar ratio of hydroxypropyl-β-cyclodextrin (HP- β-CD) to PS and substrate concentrations were the two most significant factors affecting androstenedione production.
Journal ArticleDOI
Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies.
Thao Do Thi,Koen Nauwelaerts,Matheus Froeyen,Luc Baudemprez,Michiel Van Speybroeck,Patrick Augustijns,Pieter Annaert,Johan A. Martens,Jan Van Humbeeck,Guy Van den Mooter +9 more
TL;DR: Two possibilities of complex formation are proposed: (1) methylprednisolone enters HP-beta-CD from the wider rim by its D and C ring, and (2) the A and B ring of methyl Prednisol one enters deeper in to the CD cavity so that a part of the A ring of steroidal structure is outside of the cavity.
Journal ArticleDOI
Preparation of composite particles of hydrophilic or hydrophobic drugs with highly branched cyclic dextrin via spray drying for dry powder inhalers
TL;DR: In this paper, the authors investigated the feasibility of using highly branched cyclic dextrin (HBCD) as an additive agent for dry powder inhalers (DPIs).
Journal ArticleDOI
Solid Dispersion: An Alternative Technique for Bioavailability Enhancement of Poorly Soluble Drugs
TL;DR: In this paper, a review of the strategies used for overcoming stability and scale up problems associated with solid dispersion in water-soluble carriers is presented, as well as the properties of such carriers that are being unraveled lately.
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Study of the complexation behavior of tenoxicam with cyclodextrins in solution: improved solubility and percutaneous permeability.
TL;DR: The presence of MβCD improved the percutaneous penetration of TEN through abdominal rat skin by increasing the solubility of the drug in the vehicle and by affecting the partitioning behavior of T EN in the skin.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.