Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Formation of natamycin:cyclodextrin inclusion complexes and their characterization.
John L. Koontz,Joseph E. Marcy +1 more
TL;DR: Thenatamycin:CD inclusion complexes resulted in in vitro antifungal activity nearly equivalent to that of natamycin in its free state, and the water solubility was increased 16-fold, 73-fold and 152-fold with beta- CD, gamma-CD, and HP beta-cd, respectively.
Journal ArticleDOI
Production of pure drug nanocrystals and nano co-crystals by confinement methods.
TL;DR: This review analyzes the processes for the preparation of nanocrystals and co‐crystals, divided by top‐down and bottom‐up approaches, together with their combinations and concludes that the combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes.
Journal ArticleDOI
When can cyclodextrins be considered for solubilization purposes
TL;DR: The cyclodextrin utility number, U(CD), a dimensionless number, is introduced to assess the feasibility of the use of CDs in dosage forms and was been extended to ionizable drugs that show synergistic increase in solubility due to ionization and complexation.
Journal ArticleDOI
The effects of organic salts on the cyclodextrin solubilization of drugs
TL;DR: In this article, a β-cyclodextrin (βCD) solubilization of hydrocortisone is enhanced by including short-chain anionic and cationic species in the aqueous complexation medium.
Journal ArticleDOI
pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs.
TL;DR: In this work, the LLPS concentration of three weakly basic compounds-clotrimazole, nicardipine, and atazanavir-was determined as a function of pH using three different methods and was compared to the predicted amorphoussolubility, which was calculated from the pH-dependent crystalline solubility and by estimating the free energy difference between the amorphOUS and crystalline forms.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.