Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Drug Delivery Strategies for Poorly Water-Soluble Drugs
Alfred Fahr,Xiangli Liu +1 more
TL;DR: The emerging formulation designs for delivering of poorly water-soluble drugs, including the massive use of surface-active excipients for solubilisation, are addressed.
Journal ArticleDOI
Cyclodextrin-based controlled drug release system.
Fumitoshi Hirayama,Kaneto Uekama +1 more
TL;DR: In an oral drug delivery system (DDS), the hydrophilic and ionizable CDs can serve as potent drug carriers in the immediate release- and delayed release-formulations, respectively, while the release rate of water-soluble drugs can be retarded by hydrophobic CDs.
Journal ArticleDOI
Biotechnological applications of cyclodextrins
TL;DR: Recent applications of CDs in pharmaceuticals with a major emphasis on drug delivery systems are described and the utility of these water-soluble cyclic glucans in a variety of foods, flavors cosmetics, packaging and textiles is elaborated.
Journal ArticleDOI
Cyclodextrins: structure, physicochemical properties and pharmaceutical applications
TL;DR: How too much or too little CD can hamper drug bioavailability, and the role of CDs in solid dosage forms and parenteral formulations, is explained, and examples given on how CDs can enhance drug delivery after ocular, nasal and pulmonary administration.
Journal ArticleDOI
Cyclodextrins in topical drug formulations: theory and practice
Thorsteinn Loftsson,Már Másson +1 more
TL;DR: It appears that cyclodextrins can only enhance topical drug delivery in the presence of water.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.