Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
Cyclodextrins in Parenteral Formulations.
TL;DR: The physiochemical and biological properties of CDs are reviewed as well as their pharmacokinetics after intravenous administration, and some examples are given of how CDs are applied in aqueous parenteral formulations, how their solubilizing effect has been enhanced and how their target concentration is determined.
Journal ArticleDOI
Preparation of a novel anti-fouling β-cyclodextrin–PVDF membrane
TL;DR: In this paper, a novel β-cyclodextrin (β-CD)-PVDF membrane was prepared via an interfacial reaction, using Trimesoyl Chloride (TMC) and β-CD as cross-linking and modification agents, respectively.
Journal ArticleDOI
A novel oral delivery system consisting in "drug-in cyclodextrin-in nanostructured lipid carriers" for poorly water-soluble drug: vinpocetine
Congcong Lin,Fen Chen,Tiantian Ye,Lina Zhang,Wenji Zhang,Dandan Liu,Wei Xiong,Xinggang Yang,Weisan Pan +8 more
TL;DR: A new delivery system based on drug cyclodextrin (CD) complexation and loading into nanostructured lipid carriers (NLC) to improve the oral bioavailability of vinpocetine (VP) significantly improved bioavailability and demonstrated a perspective way for oral delivery of poorly water-soluble drugs.
Journal ArticleDOI
Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery.
Michael M. Morgen,Ajay Saxena,Xue-Qing Chen,Warren K. Miller,Richard A. Nkansah,Aaron K. Goodwin,Jon Cape,Roy Haskell,Ching Su,Olafur S. Gudmundsson,Michael J. Hageman,Anoop Kumar,Gajendra Singh Chowan,Abhijith Rao,Vinay K. Holenarsipur +14 more
TL;DR: Use of lipophilic salts is a valuable approach for delivering poorly soluble compounds at high doses in Discovery, and trends in dose‐dependent exposure for various formulations were consistent with GastroPlus™ modeling.
Journal ArticleDOI
The mechanism of bensulfuron-methyl complexation with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin and effect on soil adsorption and bio-activity.
TL;DR: An approach to develop a novel CDs-based formulation for hydrophobic herbicides with lower soil adsorption and herbicidal activity in the complexation form with β-CD or 2-HP-β-CD than in the pure form is provided.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.