Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Control of the Rheological Properties in Solutions of a Polyelectrolyte and an Oppositely Charged Surfactant by the Addition of Cyclodextrins
TL;DR: In this article, ionic surfactants to polyelectrolytes, having charge opposite to that of the added surfactant, can result in pronounced effects on the system viscosity and can lead to lead...
Journal ArticleDOI
Controlled Delivery Systems: From Pharmaceuticals to Cells and Genes
TL;DR: The present state-of-the-art DDS is described, with examples of current clinical applications, and the promises and challenges for the future in this innovative field are described.
Journal ArticleDOI
Effect of commonly used vehicles on gastrointestinal, renal, and liver function in rats.
TL;DR: The effects of selected vehicles having different chemical characteristics on gastrointestinal, renal, and liver function were investigated and no "best" vehicle could be identified that may be used in each test system.
Journal ArticleDOI
Sugammadex: a novel agent for the reversal of neuromuscular blockade.
TL;DR: Sugammadex is a new modified γ‐cyclodextrin compound under clinical investigation in the United States and provides a novel mechanism of action for reversal of the neuromuscular block induced by nondepolarizing aminosteroidal agents.
Journal ArticleDOI
Carotenoids and β-cyclodextrin inclusion complexes: Raman spectroscopy and theoretical investigation.
Vanessa E. de Oliveira,Eduardo Walneide C. Almeida,Harlem V. Castro,Howell G. M. Edwards,Hélio F. Dos Santos,Luiz Fernando C. de Oliveira +5 more
TL;DR: The results discussed here clearly demonstrate the matrix effect on the carotenes' spectroscopic profile and should contribute to fully characterize the raw samples.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.