Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Recognition mechanism of D-and L-tryptophan enantiomers using 2-hydroxypropyl-α-or β-cyclodextrins as chiral selectors
Luiz Fernando B. Malta,Yraima Cordeiro,Luzineide W. Tinoco,Cora Cunha Campos,Marta Eloisa Medeiros,Octavio A. C. Antunes +5 more
TL;DR: It is determined that, together with charged groups of tryptophan ( NH 3 + and COO−), the indole moiety is the third guest interaction point with the cyclodextrin.
Journal ArticleDOI
Surface treatments on Tencel fabric: Grafting with β‐cyclodextrin
TL;DR: In this article, the grafting of acrylamidomethylated β-cyclodextrin and monochlorotriazinyl-β-cyclodesxtrin to Tencel and the inclusion of different molecules in the free cavities of cyclodextrins were investigated.
Journal ArticleDOI
Inclusion complexes of noscapine in β-cyclodextrin offer better solubility and improved pharmacokinetics
Jitender Madan,Neerupma Dhiman,Vinod K. Parmar,Satish Sardana,Prasad V. Bharatam,Ritu Aneja,Ramesh Chandra,Anju Katyal +7 more
TL;DR: These studies propose for the first time a stable NOS–β-CD inclusion complex as an effective approach to enhance the solubility and bioavailability of NOS for anticancer therapy.
Journal ArticleDOI
Experimental and theoretical analysis of the interaction of (±)-cis-ketoconazole with β-cyclodextrin in the presence of (+)-l-Tartaric acid
Enrico Redenti,Paolo Ventura,Giovanni Fronza,Antonio Selva,Silvia Rivara,Pier Vincenzo Plazzi,Marco Mor +6 more
TL;DR: Theoretical models of the three-component interaction were built up on the basis of the available NMR data, and the model derived from a folded conformation of ketoconazole turned out to be fully consistent with the molecular assembly found in aqueous solution, as inferred from NOE experiments.
Patent
Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
TL;DR: In this article, a particulate SAE-CD composition has been proposed, which has an advantageous combination of physicochemical and morphological properties not found in known solid forms of SAE.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.