Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design.
TL;DR: The data suggested, on the whole, that the surfactants and the selected cyclodextrin seemed to best augment the extent of supersaturation but had variable benefits as stabilizers, while the pharmaceutical polymers had useful effect on supersaturating drug delivery systems but were less helpful in increasing the extentof supersaturation.
Journal ArticleDOI
Evaluation of the cytotoxicity of β-cyclodextrin derivatives: Evidence for the role of cholesterol extraction
Tamás Kiss,Ferenc Fenyvesi,Ildikó Bácskay,Judit Váradi,Éva Fenyvesi,Róbert Iványi,Lajos Szente,Arpad Tosaki,Miklós Vecsernyés +8 more
TL;DR: The correlation between the cytotoxic effect, hemolytic activity and the cholesterol complexation attributes of beta-CD derivatives is demonstrated and it is proposed that cholesterol-solubilizing properties can be a predictive factor for beta- CD cell toxicity.
Journal ArticleDOI
The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-β-cyclodextrin
TL;DR: The results of solid state studies accounted for the occurrence of mechanically- and/or thermally-induced stronger interactions in ternary than in binary systems, that in some cases led to a complete loss of NAP crystallinity.
Journal ArticleDOI
Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins
TL;DR: Difficulties in the administration of protein-based drugs provides the motivation for developing drug delivery systems (DDSs) capable of maintaining therapeutic drug levels without side effects as well as traversing the deleterious mucosal environment.
Journal ArticleDOI
Cyclodextrin-based device coatings for affinity-based release of antibiotics
TL;DR: The slow, sustained, affinity-based release of antibiotics from the CD-based networks reflects their potential as a delivery platform.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.