Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
The complexation of flurbiprofen with β-cyclodextrin: a NMR study in aqueous solution
TL;DR: In this paper, the stoichiometry of the complex was determined by the method of continuous variation, using the chemical induced shifts of both host and guest protons, and the association constant, Ka of the obtained complex was calculated and found to be 2483.8 M−1.
Journal ArticleDOI
Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β- cyclodextrin derivative
Takako Ishiguro,Eri Morishita,Daisuke Iohara,Fumitoshi Hirayama,Koki Wada,Keiichi Motoyama,Hidetoshi Arima,Kaneto Uekama +7 more
TL;DR: It was suggested from the solubility study of membrane components that HB-β-CyD interacted predominantly with cholesterol in erythrocytes, resulting in the hemolysis, and HB- β-CyDs have considerable pharmaceutical potential and can work as a fast-dissolving carrier for poorly water-soluble drugs.
Journal ArticleDOI
Characterization of permethylated β-cyclodextrin-peptide noncovalently bound complexes using electron capture dissociation mass spectrometry (ECD MS)
TL;DR: In this article, electron capture dissociation mass spectrometry (ECD MS) was carried out for a number of β-permethylated cyclodextrin (CD)-peptide noncovalent complexes in a Fourier transform ion cyclotron resonance (FTICR) mass analyzer.
Journal ArticleDOI
Urea phosphate/β-cyclodextrin inclusion complex to enhance thermal behavior of cotton fabric
A. Abou-Okeil,A. El-Shafie +1 more
TL;DR: In this article, an inclusion complex of urea phosphate (UP) and β-cyclodextrin (βCD) was prepared under different reaction times and UP concentrations, and the results obtained indicate that the loss of weight of the treated fabrics is lower than that of untreated fabric.
Journal ArticleDOI
Structural Studies of [CpMoL2(CO)2]+ (L = NCMe, L2 = 2,2′-biimidazole) Complexes and Their Inclusion Compounds with Cyclodextrins
Cláudia C. L. Pereira,Susana S. Braga,Filipe A. Almeida Paz,Martyn Pillinger,Jacek Klinowski,Isabel S. Gonçalves +5 more
TL;DR: In this paper, a 1:1 host/guest stoichiometry was obtained for the TRIMEB adduct containing complex 1 and 2, which can be seen as slightly distorted pseudo-square pyramids, a coordination geometry commonly compared with a fourlegged piano stool.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.