Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery.
TL;DR: Results show that complexation with cyclodextrins increases drug stability at neutral conditions; furthermore, L-arginine contributed to higher drug stability.
A Mucoadhesive, Cyclodextrin-based Vaginal Cream Formulation of
Francois Marc Karel Jozef,Eric Carolus Leonarda Snoeckx,Peter Putteman,Fons Wouters,Eddy De Proost,Urbain Alfons Lieven Delaet,Marcus E. Brewster +6 more
TL;DR: Clinical investigations indicated that application of 5 g of a 2% cream was very well tolerated and itraconazole was not systemically absorbed, and studies suggested that an HPβCD-based, emulsified wax cream formulation was a useful and effective dosage form for treating vaginal candidiasis.
Journal ArticleDOI
Vibrational properties of ibuprofen–cyclodextrin inclusion complexes investigated by Raman scattering and numerical simulation
Barbara Rossi,Barbara Rossi,Paolo Verrocchio,Paolo Verrocchio,G. Viliani,G. Viliani,Ines Mancini,Graziano Guella,E. Rigo,Giorgina Scarduelli,Gino Mariotto +10 more
TL;DR: In this article, the effect of cyclodextrins on the vibrational spectra of the non-steroidal anti-inflammatory drug ibuprofen was investigated by means of Raman scattering and numerical simulation.
Journal ArticleDOI
Formation of Fine Drug Particles by Cogrinding with Cyclodextrins. I. The Use of β-Cyclodextrin Anhydrate and Hydrate
TL;DR: Cogrinding with a β-CD of higher water content can be an effective method to prepare fine drug particles at the submicron level to improve the micromeritical properties of pranlukast (PRK) hydrate.
Journal ArticleDOI
Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying technique
TL;DR: Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying technique indicated the presence of strong interactions between the components.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.