Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
Solubilization and preformulation studies on PG-300995 (an anti-HIV drug).
TL;DR: This study investigates the solubilization of a potential anti-human immunodeficiency virus agent [PG-300995 or 2-(2-thiophenyl)-4-azabenzoimidazole] for oral administration with multiple approaches including combinations of pH control and cosolvency, micellization, or complexation to improve thesolubility.
Journal ArticleDOI
Effects of aqueous solubility and dissolution characteristics on oral bioavailability of entacapone
Jouko Savolainen,Markus M. Forsberg,Hannu Taipale,Pekka T. Männistö,Kristiina Järvinen,Jukka Gynther,Pekka Jarho,Tomi Järvinen +7 more
TL;DR: Evaluated aqueous solubility/dissolution profiles of entacapone in vitro, and the effect of the novel pharmaceutical excipient hydroxypropyl‐β‐cyclodextrin (HP‐ β‐CD) and its role in the poor oral bioavailability of ent ACAPone in rats.
Journal ArticleDOI
Effect of Methyl -β- Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles
Adriana Trapani,Alessia Catalano,Alessia Carocci,Antonio Carrieri,Annalisa Mercurio,Antonio Rosato,Delia Mandracchia,Giuseppe Tripodo,Brigida Immacolata Pia Schiavone,Carlo Franchini,Ernesto Mesto,Emanuela Schingaro,Filomena Corbo +12 more
TL;DR: The results herein presented support the mechanisms focusing on the interactions of the bacterial membrane with CD complexes more than thoseocusing on the improvement of dissolution properties consequent to CD complexation.
Journal ArticleDOI
Encapsulation of boswellic acid with β- and hydroxypropyl-β-cyclodextrin: Synthesis, characterization, in vitro drug release and molecular modelling studies
TL;DR: In this article, a group of pentacyclic triterpenes present in gum-resin of Boswellia serrata were synthesized and their drug release profiles were studied by phase solubility studies.
Journal ArticleDOI
Hyperbranched polyamidoamines containing beta-cyclodextrin for controlled release of chlorambucil.
TL;DR: The controlled-release experiments show that the presence of beta-CD can appropriately slow the release of CLB from HPMA-beta-CDs and adjust the ratio ofCLB released in total drug loading.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.