Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin
TL;DR: The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily.
Journal ArticleDOI
Effect of preparation processes and structural insight into the supermolecular system: Bisacodyl and β-cyclodextrin inclusion complex.
TL;DR: It was found that acid solution and low temperature were unfavorable for formation of bisacodyl · β- CD and the pyridine moiety was suggested to be enclosed in the hydrophobic cavity of β-CD.
Journal ArticleDOI
Synergistic effect of Cu-nanoparticles and β-cyclodextrin functionalized reduced graphene oxide nanocomposite on the adsorptive remediation of tetracycline antibiotics.
TL;DR: In this article, copper nanoparticles immobilized-β-cyclodextrin functionalized reduced graphene oxide (Cu/β-CD/rGO) were successfully prepared as an efficient extractor of tetracycline (TC), oxytetracyCLine (OTC) and doxycycline (DC) antibiotics from different environmental water samples.
Journal ArticleDOI
Properties of Cassava Starch Modified by Amylomaltase from Corynebacterium glutamicum
Pitcha Suriyakul Na Ayudhaya,Piamsook Pongsawasdi,Kalaya Laohasongkram,Saiwarun Chaiwanichsiri +3 more
TL;DR: Amylomaltase (α-1,4-glucanotransferase, AM; EC 2.4.1.25) from Corynebacterium glutamicum expressed in Escherichia coli was used to prepare the enzyme-modified cassava starch for food application and showed an improvement in the thermo-reversibility property.
Journal ArticleDOI
Overview of intranasally delivered peptides: key considerations for pharmaceutical development.
TL;DR: The goals of this undertaking were to build a database of the key physicochemical and pharmacokinetic properties of peptide delivered by the nasal route, to evaluate formulation attributes applied to IN peptide delivery systems, and to provide key considerations for IN delivery of peptides.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.