Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Characterization of the host-guest complex of a curcumin analog with β-cyclodextrin and β-cyclodextrin-gemini surfactant and evaluation of its anticancer activity.
Masoomeh Poorghorban,Umashankar Das,Osama Alaidi,Jackson M. Chitanda,Deborah Michel,Jonathan R. Dimmock,Ronald E. Verrall,Pawel Grochulski,Ildiko Badea +8 more
TL;DR: The formation of host–guest complexes of NC 2067 with CD or CDgemini surfactant shows good potential to be used as a delivery system for anticancer agents and has been confirmed.
Journal ArticleDOI
Cetirizine release from cyclodextrin formulated compressed chewing gum
TL;DR: Physical mixtures suitable for use in cetirizine/CD formulations instead the complexes with respect to release yield may be avoided, avoiding unnecessary expenses for the complex preformulation.
Dissolution Enhancement of Poorly Soluble Drugs by Using Complexation Technique - A Review
TL;DR: In this paper, a comprehensive literature survey was made collect the rightful utilization of cyclodextrins as complexing, solubility enhancing agents and highlight the applications with these approaches.
Journal ArticleDOI
Kinetic measurements of the hydrolytic degradation of cefixime: effect of Captisol complexation and water-soluble polymers.
TL;DR: A strong stabilizing influence of the cefixime‐Captisol complexation and hypromellose was observed against aqueous mediated degradation, as compared with povidone and macrogol, which may have been due to the steric hindrance.
Journal ArticleDOI
Stilbenoid pterostilbene complexed with cyclodextrin preserves left ventricular function after myocardial infarction in rats: possible involvement of thiol proteins and modulation of phosphorylated GSK-3β.
Denise dos Santos Lacerda,Vanessa Duarte Ortiz,Patrick Turck,Cristina Campos-Carraro,Alexsandra Zimmer,Rayane Brinck Teixeira,Sara Elis Bianchi,Alexandre Luz de Castro,Paulo Cavalheiro Schenkel,Adriane Belló-Klein,Valquiria Linck Bassani,Alex Sander da Rosa Araujo +11 more
TL;DR: Overall, the PTS:HPβCD complex modulates activity of thiol-dependent enzymes and induces to the expression of antioxidant proteins, improving systolic function and mitigating the adverse cardiac remodelling post infarction.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.