Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Exploiting the Phenomenon of Liquid-Liquid Phase Separation for Enhanced and Sustained Membrane Transport of a Poorly Water-Soluble Drug.
TL;DR: A first-principles mathematical model was developed which was able to fit the experimental receiver concentration-time profiles for concentration regimes both below and above amorphous solubility, providing support for the contention that the nanodroplet phase does not directly diffuse across a membrane but, instead, rapidly replenishes the drug in the aqueous phase that has been removed by transport across the membrane.
Journal ArticleDOI
Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats.
Hidetoshi Arima,Kiyokazu Yunomae,Kouzou Miyake,Tetsumi Irie,Fumitoshi Hirayama,Kaneto Uekama +5 more
TL;DR: DM-beta-CyD is particularly useful in designing oral preparations of tacrolimus with an enhanced bioavailability and a reduced variability in absorption, according to the results of an in vivo study.
Journal ArticleDOI
Amorphous formulations for dissolution and bioavailability enhancement of poorly soluble APIs
TL;DR: In this paper, the authors discuss the need for active pharmaceutical ingredients (APIs) in the amorphous state, use of several techniques to amorphize APIs and enhance the stability of API under stress test conditions.
Journal ArticleDOI
Comparative interaction of 2-hydroxypropyl-β-cyclodextrin and sulfobutylether-β-cyclodextrin with itraconazole: Phase-solubility behavior and stabilization of supersaturated drug solutions
Marcus E. Brewster,Roger Petrus Gerebern Vandecruys,Jef Peeters,Peter Neeskens,Geert Verreck,Thorsteinn Loftsson +5 more
TL;DR: Hydrophilic cyclodextrins might be useful formulation adjuncts in supersaturating drug delivery systems and are found to stabilize concentrations of itraconazole significantly in excess of their equilibrium solubility when supersaturated solutions were formed using the co-solvent/solvent quench approach.
Journal ArticleDOI
Cyclodextrins and ternary complexes: technology to improve solubility of poorly soluble drugs
Janisse Crestani de Miranda,Tércio Elyan Azevedo Martins,Francisco Veiga,Humberto Gomes Ferraz +3 more
TL;DR: In this paper, the authors address aspects related to drug complexation with CDs using water-soluble polymers to optimize the amount of CD used in the formulation in order to increase drug solubility and reduce dosage form volume.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.