Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Cyclodextrins and their uses: a review
TL;DR: Cyclodextrins are a family of cyclic oligosaccharides composed of α-(1,4) linked glucopyranose subunits.
Journal ArticleDOI
Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
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Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.
Journal ArticleDOI
Cyclodextrin-based pharmaceutics: past, present and future
Mark E. Davis,Marcus E. Brewster +1 more
TL;DR: Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
References
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Journal ArticleDOI
Aspects of the chemical stability of doxorubicin and seven other anthracyclines in acidic solution.
TL;DR: The degradation of doxorubicin in acidic medium has been investigated using a stability indicating high pressure liquid chromatographic assay and the aglycone degradation products are characterized by mass spectrometry and by chromatography.
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Effect of 2-Hydroxypropyl-β-cyclodextrin on Crystallization and Polymorphic Transition of Nifedipine in Solid State
TL;DR: The present data suggest that HP-β-CyD is useful for the preparation of a fast dissolving form of metastable NP through glassy NP, and its crystallization and polymorphic transition behavior was investigated.
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The effect of a modified beta-cyclodextrin, SBE4-beta-CD, on the aqueous stability and ocular absorption of pilocarpine.
TL;DR: SBE4-beta-CD did not damage the corneal epithelium in vitro and was well-tolerated by the rabbit eye in vivo, suggesting that indeed, pilocarpine does interact with SBE4, modified beta-cyclodextrin.
Journal ArticleDOI
Effect of various cyclodextrins on solution stability and dissolution rate of doxorubicin hydrochloride
Marcus E. Brewster,Thorsteinn Loftsson,Thorsteinn Loftsson,Kerry S. Estes,Jun-Liang Lin,Hafrún Fridriksdóttir,Nicholas Bodor +6 more
TL;DR: A number of cyclodextrins were examined as to their ability to stabilize doxorubicin in solution and to enhance the rate of its dissolution as mentioned in this paper, and the results showed that the modified Cyclodextrin is innocuous even when given in large doses parenterally.
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Complexation of moricizine with nicotinamide and evaluation of the complexation constants by various methods
TL;DR: The enhancement of solubility of moricizine near physiologic pH via complexation with nicotinamide was examined as a potential solubilization technique.