Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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Immunological exhaustion and functional profile of CD8+ T lymphocytes as cellular biomarkers of therapeutic efficacy in chronic Chagas disease patients.
Elena Pérez-Antón,Adriana Egui,María del Carmen Thomas,Marina Simón,Manuel Segovia,Manuel Carlos López +5 more
TL;DR: Improvement of the functional capacity of CD8+ T cells after treatment is shown, which could be have a positive effect on parasitic control.
Journal ArticleDOI
Dominant TNFα and impaired IL-2 cytokine profiles of CD4 + T cells from children with type-1 diabetes
Julia Seyfarth,Katharina Förtsch,Heinz Ahlert,Hans-Juergen Laws,Beate Karges,René Deenen,Karl Köhrer,Ertan Mayatepek,Thomas Meissner,Marc Jacobsen +9 more
TL;DR: It is concluded that long‐term symptomatic type‐1‐diabetes patients differed in memory T‐cell cytokine profiles and Interleukin‐7 co‐stimulation.
Journal ArticleDOI
Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings
Victor S. Ferreira,J. Solera,Queenie Hu,V. Hall,Berta G Arbol,W. Rod Hardy,Reuben Samson,Tina Marinelli,Matthew Ierullo,Avneet Kaur Virk,Alexandra Kurtesi,Faranak Mavandadnejad,Beata Majchrzak-Kita,Vathany Kulasingam,Anne-Claude Gingras,Deepali Kumar,Atul Humar +16 more
TL;DR: In this paper , the authors compared homotypic and heterotypic humoral and cellular immune responses to Omicron BA.1 in organ transplant patients across a diverse clinical spectrum.
Journal ArticleDOI
Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults
Miguel Ángel Palacios-Pedrero,J. H. Marco Jansen,Cornelia Blume,Nils Stanislawski,Rebecca Jonczyk,Antonia Molle,Mariana Gonzalez Hernandez,Franziska Kaiser,Klaus Jung,Albert D. M. E. Osterhaus,Guus F. Rimmelzwaan,Giulietta Saletti +11 more
TL;DR: In this paper , the authors investigated adaptive immune responses in adults of various ages (22-99 years old) receiving 2 doses of the BNT162b2 mRNA vaccine and identified signs of immunosenescence correlating with the outcome of vaccination against a new viral antigen to which older adults are immunologically naïve.
Journal ArticleDOI
Cell-Mediated Immune Responses After Influenza Vaccination of Solid Organ Transplant Recipients: Secondary Outcomes Analyses of a Randomized Controlled Trial
Arnaud G L'Huillier,Victor H Ferreira,Cedric Hirzel,Yoichiro Natori,Jaclyn Slomovic,Terrance Ku,Katja Hoschler,Matthew Ierullo,Nazia Selzner,Jeffrey Schiff,Lianne G. Singer,Atul Humar,Deepali Kumar +12 more
TL;DR: This study provides novel evidence that HD vaccine elicits greater cellular responses compared to the SD vaccine in SOT recipients, which provides support to preferentially consider use of HD vaccination in the SOT setting.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
TL;DR: Gko mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFNs, and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.