Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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Journal ArticleDOI
New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells
Edessa Negera,Kidist Bobosha,Stephen L. Walker,Birtukan Endale,Rawleigh Howe,Abraham Aseffa,Hazel M. Dockrell,Diana N. J. Lockwood +7 more
TL;DR: T-cell activation and the different subsets of memory T cells in untreated patients with ENL are shown, which challenges the long-standing dogma of immune complex as a sole etiology of ENL reaction.
Journal ArticleDOI
TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies
Kattria van der Ploeg,Adam Kirosingh,D. A. Mori,Saborni Chakraborty,Zicheng Hu,B. L. Sievers,Karen B. Jacobson,Hector Bonilla,Julie Parsonnet,Jason R. Andrews,K. Press,Maureen C. Ty,Daniel Ruiz-Betancourt,Lauren de la Parte,Gene S. Tan,Catherine A. Blish,Saki Takahashi,Isabel Rodriguez-Barraquer,Bryan Greenhouse,Upinder Singh,Taia T. Wang,Prasanna Jagannathan +21 more
TL;DR: Wherry et al. as discussed by the authors characterized SARS-CoV-2-specific CD4+ T cells in a longitudinal cohort of 109 COVID-19 outpatients enrolled during acute infection.
Emerging Concepts in the Immunopathogenesis
TL;DR: This review covers the role of immune activation in HIV immunopathogenesis, how that activation could be mediated directly by HIV replicating within and damaging the gut mucosal bar- rier, how HIV affects multiple T cell functions and phenotypes, and how chronic HIV replication induces immune modulatory pathways to negatively regulate certain functions in HIV-specific T cells.
Journal ArticleDOI
Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers.
Tone Otterhaug,Sylvia Janetzki,Marij J. P. Welters,Monika Håkerud,Anne Grete Nedberg,Victoria Tudor Edwards,Sanne Boekestijn,Nikki M. Loof,Pål Kristian Selbo,Hans Olivecrona,Sjoerd H. van der Burg,Anders Høgset +11 more
TL;DR: In this paper, the safety, tolerability, and immune response to PCI vaccination in combination with the adjuvant poly-ICLC (Hiltonol) was evaluated in healthy volunteers.
Journal ArticleDOI
Erratum: T-cell quality in memory and protection: implications for vaccine design
TL;DR: In Figure 5b and Figure 5c, the terms “high” and “low” were reversed.
References
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Journal Article
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TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
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An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
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Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.