Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
More filters
Journal ArticleDOI
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses.
Joyce Wei,Welby Montalvo-Ortiz,Lola Yu,Amanda Krasco,Sarah Ebstein,Czrina Cortez,Israel Lowy,Andrew J. Murphy,Matthew A. Sleeman,Dimitris Skokos +9 more
TL;DR: In this paper, the authors analyzed the antitumor responses at primary and distal tumor sites, demonstrating that the timing of αPD-1 antibody administration relative to radiotherapy determined the potency of the induced abscopal response.
Journal ArticleDOI
Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization.
TL;DR: The 200 nm NPs are a very interesting antigen nanocarrier for prophylactic vaccines against mucosal pathogens that require multifunctional CD4(+) T cells for protection and may be useful to engineer subunit vaccines able to elicit appropriate mucosal immune responses that correlate with protection.
Journal ArticleDOI
Ever closer to a prophylactic vaccine for HCV
TL;DR: The current candidate vaccines for HCV are introduced and how these fare against the expected requirements of an effective prophylactic HCV vaccine in relation to the breadth, functionality, magnitude and phenotype of the vaccine-induced immune response are compared.
Journal ArticleDOI
Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses.
Christelle Liard,Séverine Munier,Mauricio A. Arias,Alix Joulin-Giet,Olivia Bonduelle,Darragh Duffy,Robin J. Shattock,Bernard Verrier,Béhazine Combadière +8 more
TL;DR: This work demonstrated that SC immunization induced HIV-1 p24 specific IgG in absence of antigen-specific CD8 T cells, whereas the ID route induced both cellular and humoral responses.
Journal ArticleDOI
Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates.
Thomas W. Geisbert,Michael Bailey,Joan B. Geisbert,Clement Asiedu,Mario Roederer,Maria Grazia-Pau,Jerome Custers,Peter B. Jahrling,Jaap Goudsmit,Richard A. Koup,Nancy J. Sullivan +10 more
TL;DR: Regimens using DNA plasmids modified for optimal antigen expression and recombinant adenovirus (rAd) vectors, all encoding the glycoprotein (GP) gene from Angola Marburg virus, were compared for their ability to provide immune protection against lethal MARV Angola infection.
References
More filters
Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
TL;DR: Gko mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFNs, and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.