Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials
Sarah Kutscher,Claudia J. Dembek,Simone Deckert,C Russo,Nina Körber,Johannes R. Bogner,Fabian Geisler,Andreas Umgelter,Michael Neuenhahn,Julia Albrecht,Antonio Cosma,Ulrike Protzer,Tanja Bauer +12 more
TL;DR: Overnight resting of PBMC prior to ex vivo analysis of antiviral T-cell responses represents an efficient method to increase sensitivity of ICS-based methods and has a prominent impact on the functional phenotype of T cells.
Journal ArticleDOI
Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells.
Caroline Boudousquie,Giovanna Bossi,Jacob Hurst,Karolina A. Rygiel,Bent K. Jakobsen,Namir J. Hassan +5 more
TL;DR: It is demonstrated that IMCgp100 induces broad immune responses that extend beyond the induction of CD8+ T cell‐mediated cytotoxic activity, which is a hallmark of a potent anti‐cancer response.
Journal ArticleDOI
Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice
Elizabeth Ahern,Heidi Harjunpää,Heidi Harjunpää,Deborah S. Barkauskas,Stacey Allen,Kazuyoshi Takeda,Hideo Yagita,David Wyld,David Wyld,William C. Dougall,William C. Dougall,Michele W.L. Teng,Michele W.L. Teng,Mark J. Smyth,Mark J. Smyth +14 more
TL;DR: A rationale for the further investigation of RANKL–RANK interactions in tumor immunity is provided and a basis for development of translational markers of interest in human clinical trials.
Journal ArticleDOI
T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy.
Rikke Andersen,Marie Christine Wulff Westergaard,Julie Westerlin Kjeldsen,Anja Müller,Natasja Wulff Pedersen,Sine Reker Hadrup,Özcan Met,Barbara Seliger,Bjarne Kromann-Andersen,Thomas Hasselager,Marco Donia,Inge Marie Svane +11 more
TL;DR: TILs isolated from primary RCC specimens could recognize tumors, however, their immune responses were weaker than TILs from metastatic melanoma and displayed a mono-/oligo-functional pattern, suggesting the ability to select and expand poly-functional T cells may improve cell therapy for RCC.
Journal ArticleDOI
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination
Kaatje Smits,Gaelle Pottier,Julie Smet,Violette Dirix,Françoise Vermeulen,Iris De Schutter,Maria Carollo,Camille Locht,Clara M. Ausiello,Françoise Mascart +9 more
TL;DR: This study supports at the immunological level recent epidemiological studies indicating that infant vaccination with wP induces longer lasting immunity than vaccination with aP-vaccines.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
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Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.