Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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Journal ArticleDOI
Helping Themselves: Optimal Virus-Specific CD4 T Cell Responses Require Help via CD4 T Cell Licensing of Dendritic Cells
Matthew R. Olson,Shirley G K Seah,Jolie G. Cullen,Marie Greyer,Kathryn M. Edenborough,Peter C. Doherty,Sammy Bedoui,Andrew M. Lew,Stephen J. Turner +8 more
TL;DR: Activation of adoptively transferred Th cells during primary influenza A virus (IAV) infection enhances both the magnitude and functional breadth of endogenous primary IAV-specific CD4+ T cell responses.
Journal ArticleDOI
The Profile of T Cell Responses in Bacille Calmette-Guérin-Primed Mice Boosted by a Novel Sendai Virus Vectored Anti-Tuberculosis Vaccine.
Zhidong Hu,Ling Gu,Chun-Ling Li,Tsugumine Shu,Douglas B. Lowrie,Douglas B. Lowrie,Xiao-Yong Fan,Xiao-Yong Fan +7 more
TL;DR: The data strongly suggest that the enhanced immune protection induced by SeV85AB boosting was associated with establishment of an increased capacity to recall antigen-specific IL-2-mediated T cell responses and confirms this Sendai virus vector system as a promising candidate to be used in a heterologous prime-boost immunization regimen against TB.
Journal ArticleDOI
Bolstering Components of the Immune Response Compromised by Prior Exposure to Adenovirus: Guided Formulation Development for a Nasal Ebola Vaccine
TL;DR: A panel of formulations was evaluated by an in vitro assay for their ability to protect rAd from neutralization and revealed that F16 promoted strong levels of transgene expression in naive mice and those that were exposed to adenovirus in the nasal cavity 28 days prior to immunization.
Journal ArticleDOI
Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.
Anya Lissina,David R. Ambrozak,Kristin L. Boswell,Wenjing Yang,Eli Boritz,Yoshiyuki Wakabayashi,Maria Candela Iglesias,Maria Candela Iglesias,Masao Hashimoto,Masafumi Takiguchi,Elias K. Haddad,Daniel C. Douek,Jun Zhu,Richard A. Koup,Takuya Yamamoto,Victor Appay,Victor Appay +16 more
TL;DR: It is shown that the 2B4‐CD48 axis is involved in the fine‐tuning of CD8+ T‐cell effector function upon antigenic stimulation, and this results imply a variable contribution of the 2 B4‐ CD48 interaction to the modulation ofCD8-T‐cell functional properties, potentially linked to intrinsic levels of T‐bet expression and TCR avidity.
Dissertation
The Effect of Cytomegalovirus infection on Follicular Lymphoma biology
TL;DR: The hypotheses that CMV infection in FL is associated with accelerated immune senescence with the accumulation of exhausted T cells and reduced cytokine production are supported.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
TL;DR: Gko mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFNs, and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.