Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
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Escape from highly effective public CD8+ T-cell clonotypes by HIV
Maria Candela Iglesias,Jorge R. Almeida,Jorge R. Almeida,Solène Fastenackels,David van Bockel,Masao Hashimoto,Vanessa Venturi,Emma Gostick,Alejandra Urrutia,Linda Wooldridge,Mathew Clement,Stephanie Gras,Pascal G. Wilmann,Brigitte Autran,Arnaud Moris,Jamie Rossjohn,Miles P. Davenport,Masafumi Takiguchi,Christian Brander,Daniel C. Douek,Anthony D. Kelleher,David Price,David Price,Victor Appay +23 more
TL;DR: Detailed mechanistic insights are provided into the workings of an effective CD8(+) T-cell response against HIV, found to be preferentially selected in vivo and shared between individuals.
Journal ArticleDOI
Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells.
TL;DR: The levels of vaccine-induced pulmonary and splenic protective immunity correlated with the frequency and the integrated MFI values of triple-positive CD4 T cells that were induced by the same vaccines, which support efforts to use MFT cell analyses as a measure of TB vaccine immunogenicity in human immunization studies.
Journal ArticleDOI
How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
TL;DR: It is observed that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses, and the effect of delaying the second injection is assessed.
Journal ArticleDOI
Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5- Th2 responses
TL;DR: IL-5+ T(H)2 food allergen-specific T cells are singularly associated with AEG, whereas PA is associated with a dominant IL-5(-) T(h)2 response, which suggests heterogeneity within the T( H)2 cytokine response.
Journal ArticleDOI
Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination
TL;DR: Induction of polyfunctional CD4+ T cells is certainly not sufficient and may not even be necessary to mediate protection and it is suggested that other functional attributes, such as additional effector functions, T cell differentiation state, tissue homing potential, or long-term survival capacity of the T cell may be equally or more important to promote protection.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
TL;DR: Gko mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFNs, and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.