Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.
Jun Du,Zhi-yuan Wu,Shu-rong Ren,Shu-rong Ren,Yong Wei,Mei-Hua Gao,Gwendalyn J. Randolph,Chunfeng Qu +7 more
TL;DR: The results suggest that TLR8 agonists are good candidates to enhance recombinant HBsAg immunogenicity to induce specific humoral and cellular immune responses.
Journal ArticleDOI
Tissue Specificity of Cross-Reactive Allogeneic Responses by EBV EBNA3A-Specific Memory T Cells
Lloyd D'Orsogna,Dave L. Roelen,Ellen M.W. van der Meer-Prins,Pieter van der Pol,Marry E.I. Franke-van Dijk,M. Eikmans,J. Anholts,Jamie Rossjohn,James McCluskey,Arend Mulder,Cees van Kooten,Ilias I.N. Doxiadis,Frans H. J. Claas +12 more
TL;DR: It is reported that allogeneic HLA-B*44:02+ proximal tubular epithelial cells (PTECs) and human umbilical vein endothelial cells and HUVECs are poor targets for EBV EBNA3A-specific T cells.
Journal ArticleDOI
An α-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major.
Eva Iniguez,Nathaniel S. Schocker,Krishanthi Subramaniam,Susana Portillo,Alba Montoya,Waleed S. Al-Salem,Caresse L. Torres,Felipe Rodriguez,Otacilio C. Moreira,Alvaro Acosta-Serrano,Katja Michael,Igor C. Almeida,Rosa A. Maldonado +12 more
TL;DR: It is proposed that NGP5B is an attractive candidate for the study of potential synthetic α-Gal-neoglycoprotein-based vaccines against L. major, and a robust humoral and cellular immune response with production of high levels of protective lytic anti-α-Gal antibodies and induction of Th1 cytokines is observed.
Journal ArticleDOI
Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination.
Ankit Mittal,Kai Schulze,Thomas Ebensen,Sebastian Weissmann,Steffi Hansen,Carlos A. Guzmán,Claus-Michael Lehr +6 more
TL;DR: The study showed enhanced stability and encapsulation efficacy of the antigen when encapsulated in IMSG NPs in comparison to polylactic-co-glycolic acid (PLGA) and chitosan-PLGA NPs and the possibility of improving the immune response elicited by co-encapsulating the adjuvant bis-(3',5')-cyclic dimeric adenosine monophosphate and OVA within one particulate carrier system.
Journal ArticleDOI
The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection
TL;DR: The respiratory burst increases with severity of liver cirrhosis but is restrained by increasing LBP levels, and a positive correlation between ab‐oxLDL and ROS release was observed.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
TL;DR: Gko mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFNs, and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.