Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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Journal ArticleDOI
Simultaneous Infiltration of Polyfunctional Effector and Suppressor T Cells into Renal Cell Carcinomas
Sebastian Attig,Jörg Hennenlotter,Graham Pawelec,Gerd Klein,Sven D. Koch,Hanspeter Pircher,Susan Feyerabend,Dorothee Wernet,Arnulf Stenzl,Hans-Georg Rammensee,Cécile Gouttefangeas +10 more
TL;DR: Analysis of subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex vivo following mechanical disaggregation and without any culture step finds several populations of CD4(+) and CD8(+) regulatory T cells were identified that may synergize to locally dampen antitumor T-cell responses.
Journal ArticleDOI
Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques
Wen-Hsuan W. Lin,Diane E. Griffin,Paul A. Rota,Mark J. Papania,Stephen P. Cape,David L.H. Bennett,Brian T. Quinn,Robert E. Sievers,Charles D. Shermer,Kenneth G. Powell,Robert J. Adams,Steven Godin,Scott Winston +12 more
TL;DR: A novel single unit dose, dry powder live-attenuated measles vaccine (MVDP) for respiratory delivery without reconstitution was developed and was safe and effective and could aid in measles control.
Journal ArticleDOI
Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients.
An M. T. Van Nuffel,Daphné Benteyn,Sofie Wilgenhof,L. Pierret,Jurgen Corthals,Carlo Heirman,Pierre van der Bruggen,Pierre Coulie,Bart Neyns,Kris Thielemans,Aude Bonehill +10 more
TL;DR: This work provides definitive proof that DCs presenting the full antigenic spectrum of tumor antigens can induce T cells specific for novel epitopes and can be administered to patients irrespective of their HLA type.
Journal ArticleDOI
B-cell epitope mapping for the design of vaccines and effective diagnostics
TL;DR: This up-to-date review discusses and compares the different physical, computational, and molecular methods that have been used in epitope mapping and helps researchers to design the most suitable protocol for mapping their B-cell epitopes.
Journal ArticleDOI
Double- and monofunctional CD4+ and CD8+ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals
Susanna Commandeur,May Y. Lin,May Y. Lin,Krista E. van Meijgaarden,Annemieke H. Friggen,Kees L. M. C. Franken,Jan W. Drijfhout,Gro Ellen Korsvold,Fredrik Oftung,Annemieke Geluk,Tom H. M. Ottenhoff +10 more
TL;DR: The prominent presence of double‐ and monofunctional CD4+ and CD8+ T‐cell responses in naturally protected individuals are demonstrated and support the possibility of designing Mtb DosR antigen‐based TB vaccines.
References
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Journal Article
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Journal ArticleDOI
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Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.