Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
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Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial.
François Spertini,Régine Audran,Reza Chakour,Olfa Karoui,Viviane Steiner-Monard,Anne-Christine Thierry,Carole Mayor,Nils Rettby,Katia Jaton,Laure Vallotton,Catherine Lazor-Blanchet,Juana Doce,Eugenia Puentes,Dessislava Marinova,Nacho Aguilo,Carlos Martin,Carlos Martin +16 more
TL;DR: The safety of vaccination with MTBVAC at all doses was similar to that of BCG, and vaccination did not induce any serious adverse events, and data support advanced clinical development in high-burden tuberculosis endemic countries.
Journal ArticleDOI
CD4 memory T cells: What are they and what can they do?
Megan K. L. MacLeod,Eric T. Clambey,John W. Kappler,John W. Kappler,Philippa Marrack,Philippa Marrack +5 more
TL;DR: The different systems used to study CD4 memory cells are discussed and whether, and in what circumstances, memory CD4 cells could provide protection against infections are asked.
Journal ArticleDOI
Multifunctional T-cell Analyses to Study Response and Progression in Adoptive Cell Transfer Immunotherapy
Chao Ma,Ann F. Cheung,Thinle Chodon,Richard C. Koya,Zhongqi Wu,Charles Ng,Earl Avramis,Alistair J. Cochran,Owen N. Witte,David Baltimore,Bartosz Chmielowski,James S. Economou,Begonya Comin-Anduix,Antoni Ribas,James R. Heath +14 more
TL;DR: The need to develop approaches to maintaining antitumor T-cell functionality with the aim of increasing the long-term efficacy of TCR-engineered ACT immunotherapy of patients with advanced melanoma is highlighted.
Journal ArticleDOI
WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
Lee M. Krug,Tao Dao,Andrew B. Brown,Peter Maslak,William D. Travis,Sara Bekele,Tatyana Korontsvit,Victoria Zakhaleva,Jedd D. Wolchok,Jianda Yuan,Hao Li,Leslie B. Tyson,David A. Scheinberg +12 more
TL;DR: This multivalent WT1 peptide analog vaccine induces immune responses in a high proportion of patients with thoracic malignancies with minimal toxicity.
Journal ArticleDOI
CD4+ T Cells Are Necessary and Sufficient To Confer Protection against Chlamydia trachomatis Infection in the Murine Upper Genital Tract
TL;DR: It is shown that direct C. trachomatis infection of the murine upper genital tract stimulates a robust Chlamydia-specific CD4+ T cell response that is both necessary and sufficient to clear infection and provide protection against reinfection.
References
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Journal Article
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TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
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Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
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Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.