Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TLDR
The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.Abstract:
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.read more
Citations
More filters
Journal ArticleDOI
Adoptive T‐Cell Therapy of a Lung Transplanted Patient with Severe CMV Disease and Resistance to Antiviral Therapy
G. Brestrich,S Zwinger,Annika M. Fischer,M. Schmück,A. Röhmhild,Markus H. Hammer,Andreas Kurtz,Lutz Uharek,Christoph Knosalla,Hans B. Lehmkuhl,Hans-Dieter Volk,Petra Reinke +11 more
TL;DR: The successful adoptive transfer of autologousCMV‐specific T cells to a lung transplant recipient with ganciclovir‐resistant CMV‐pneumonia requiring mechanical ventilation signifies the high therapeutic potential of adoptive immunotherapy in the treatment of SOT recipients when all other measures show no effect.
Journal ArticleDOI
Phase I/II study of GM-CSF DNA as an adjuvant for a multipeptide cancer vaccine in patients with advanced melanoma.
Miguel-Angel Perales,Jianda Yuan,Sarah Powel,Humilidad F. Gallardo,Teresa S. Rasalan,Christina Gonzalez,Gregor Manukian,Jian Wang,Yan Zhang,Paul B. Chapman,Susan E. Krown,Philip O. Livingston,Samuel Ejadi,Katherine S. Panageas,Manuel E. Engelhorn,Stephanie L. Terzulli,Alan N. Houghton,Jedd D. Wolchok +17 more
TL;DR: A phase I/II trial of human GM-CSF DNA in conjunction with a multipeptide vaccine (gp100 and tyrosinase) in stage III/IV melanoma patients found it to be a safe adjuvant.
Journal ArticleDOI
Targeting innate immunity for tuberculosis vaccination.
Shabaana A. Khader,Maziar Divangahi,Willem A. Hanekom,Philip C. Hill,Markus Maeurer,Karen W. Makar,Katrin D. Mayer-Barber,Musa M. Mhlanga,Elisa Nemes,Larry S. Schlesinger,Reinout van Crevel,Ramakrishna Vankalayapati,Ramnik J. Xavier,Mihai G. Netea,Mihai G. Netea +14 more
TL;DR: Future studies are warranted to explore the untapped potential of trained immunity to develop a future generation of TB vaccines that would combine innate and adaptive immune memory induction.
Journal ArticleDOI
Bronchoalveolar CD4 + T cell responses to respiratory antigens are impaired in HIV-infected adults
Kondwani C. Jambo,Enoch Sepako,Duncan G. Fullerton,David Mzinza,Sarah J. Glennie,Adam K. A. Wright,Robert S. Heyderman,Stephen B. Gordon +7 more
TL;DR: BAL antigen-specific CD4+ T cell responses to influenza virus, Streptococcus pneumoniae and Mycobacterium tuberculosis antigens in bronchoalveolar lavage and peripheral blood between HIV-infected individuals and HIV-uninfected Malawian adults are impaired.
Journal ArticleDOI
A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses
Juan García-Arriaza,José Luis Nájera,Carmen E. Gómez,Nolawit Tewabe,Carlos Oscar S. Sorzano,Thierry Calandra,Thierry Roger,Mariano Esteban +7 more
TL;DR: It is revealed that C6 can be considered as an immunomodulator and that deleting C6L gene in MVA-B confers an immunological benefit by enhancing IFN-β-dependent responses and increasing the magnitude and quality of the T-cell memory immune responses to HIV-1 antigens.
References
More filters
Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Journal ArticleDOI
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
JoAnne L. Flynn,John Chan,Karla J. Triebold,Dyana K. Dalton,Timothy A. Stewart,Barry R. Bloom +5 more
TL;DR: Gko mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFNs, and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN.
Journal ArticleDOI
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Norimitsu Kadowaki,Stephen Ho,Svetlana Antonenko,Rene de Waal Malefyt,Robert A. Kastelein,J. Fernando Bazan,Yong-Jun Liu +6 more
TL;DR: The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.