C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Fhit tumor suppressor: guardian of the preneoplastic genome.
Flavia Pichiorri,Tiziana Palumbo,Sung-Suk Suh,Hiroshi Okamura,Francesco Trapasso,Hideshi Ishii,Kay Huebner,Carlo M. Croce +7 more
TL;DR: Fhit interacts with and stabilizes ferrodoxin reductase (Fdxr), a mitochondrial flavoprotein that transfers electrons from NADPH to cytochrome P450, suggesting a role for Fhit in the modulation of reactive oxygen species production and of genomic damage.
Patent
Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas
TL;DR: In this article, methods and compositions for the diagnosis, prognosis and/or treatment of esophageal adenocarcinoma and Barrett's esophagus associated carcinoma are disclosed.
Journal ArticleDOI
Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53−/− mouse model and primary human leukemia cells
Jinyun Liu,Gang Chen,Li Feng,Wan Zhang,Helene Pelicano,Feng Wang,Marcia A. Ogasawara,Weiqin Lu,Hesham M. Amin,Carlo M. Croce,Michael J. Keating,Peng Huang +11 more
TL;DR: In this article, a mouse model with TCL1-Tg:p53(-/-) genotype was generated to investigate the underlying mechanisms for the highly malignant phenotype of 17p-CLL and to facilitate in vivo evaluation of potential drugs against CLL with p53 deletion.
Journal Article
Characterization of t(11;14) translocation in mantle cell lymphoma by fluorescent in situ hybridization.
TL;DR: This study detected BCL-1 translocations in eight of eight patients with clinical and immunological features of mantle cell lymphoma, suggesting that the t(11;14) translocation is a critical event in the pathogenesis of MCL and may be a primary element for the diagnosis.
Journal ArticleDOI
Identification of the Genes Up- and Down-Regulated by the High Mobility Group A1 (HMGA1) Proteins: Tissue Specificity of the HMGA1-Dependent Gene Regulation
Josefina Martinez Hoyos,Monica Fedele,Sabrina Battista,Francesca Pentimalli,Mogens Kruhøffer,Claudio Arra,Torben F. Ørntoft,Carlo M. Croce,Alfredo Fusco +8 more
TL;DR: High mobility group A (HMGA) proteins are chromatinic proteins that do not have transcriptional activity per se, however, by interacting with the transcription machinery, they regulate, negatively or positively, the expression of several genes.