C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival.
TL;DR: MicroRNA-21 is significantly overexpressed in pancreatic cancers as detected by in situ hybridization and its strong expression predicts limited survival in patients with node-negative disease and may be an important biologic marker for outcome.
Journal Article
Detection of hematogenous micrometastasis in patients with prostate cancer
Jose G. Moreno,Carlo M. Croce,Rainer Fischer,Maria Monne,P Vihko,Mulholland Sg,Leonard G. Gomella +6 more
TL;DR: Contrary to a long held hypothesis, these data point to the possibility that hematogenous metastasis may be a relatively early event in the natural history of human prostate cancer.
Journal ArticleDOI
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Rosa Visone,Pierlorenzo Pallante,Andrea Vecchione,Roberto Cirombella,Manuela Ferracin,Angelo Ferraro,Stefano Volinia,Sabrina Coluzzi,Vincenza Leone,Eleonora Borbone,Chang Gong Liu,Fabio Petrocca,Giancarlo Troncone,George A. Calin,Aldo Scarpa,Chiara Colato,Giovanni Tallini,Massimo Santoro,Carlo M. Croce,Alfredo Fusco +19 more
TL;DR: Analysis of the microRNA profile of ATC in comparison to the normal thyroid using a microarray suggests a miR signature associated with ATC and suggests the miR deregulation as an important event in thyroid cell transformation.
Journal ArticleDOI
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.
Francesca Fornari,Laura Gramantieri,Catia Giovannini,Angelo Veronese,Manuela Ferracin,Silvia Sabbioni,George A. Calin,Gian Luca Grazi,Carlo M. Croce,Carlo M. Croce,Simona Tavolari,Pasquale Chieco,Massimo Negrini,Luigi Bolondi +13 more
TL;DR: It is proved that, by modulating cyclin G1, miR-122 influences p53 protein stability and transcriptional activity and reduces invasion capability of HCC-derived cell lines and is established a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment.
Journal ArticleDOI
Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor β Signaling
TL;DR: Genetic ablation of these microRNAs reveals their physiologic role in the control of liver and central nervous system apoptosis, supporting the notion that miRNA-based homeostatic mechanisms can be usurped by cancer cells to resist TGFbeta tumor suppression.