C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
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Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas
TL;DR: The mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms are discussed.
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Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes
TL;DR: The isolation and characterization of a new member of the TCL1 gene family, TCL 1b, located approximately 16 kb centromeric of TCL2, is reported, which encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1.
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Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.
Monica Fedele,Vincenzo Fidanza,Sabrina Battista,Francesca Pentimalli,Andres J. Klein-Szanto,Rosa Visone,Ivana De Martino,Antonio Curcio,Carmine Morisco,Luigi Del Vecchio,Gustavo Baldassarre,Claudio Arra,Giuseppe Viglietto,Ciro Indolfi,Carlo M. Croce,Alfredo Fusco +15 more
TL;DR: The data reported here indicate the critical role of HMGA1 in heart development and growth, and reveal an unsuspected antioncogenic potential for this gene in hematologic malignancies.
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17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition
Erin Hertlein,Amy J. Wagner,Jeffrey A. Jones,Thomas S. Lin,Kami J. Maddocks,William H. Towns,Virginia M. Goettl,Xiaoli Zhang,David Jarjoura,Chelsey A. Raymond,Derek A. West,Carlo M. Croce,John C. Byrd,Amy J. Johnson +13 more
TL;DR: Treatment with 17-DMAG leads to depletion of the HSP90 client protein IKK, resulting in diminished NF-kappaB p50/p65 DNA binding, decreased NF- kappaB target gene transcription, and caspase-dependent apoptosis, which significantly decreased the white blood cell count and prolonged the survival in a TCL1-SCID transplant mouse model.
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Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes
George A. Calin,Carlo M. Croce +1 more
TL;DR: This work focuses on the roles of miRNAs and ultraconserved ncRNA genes in CLL, highlighting what is already known about their function, proposing a novel model of CLL predisposition and progression, and describing the challenges for the near future.