C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
microRNA involvement in human cancer
Marilena V. Iorio,Carlo M. Croce +1 more
TL;DR: An increasing body of evidence has indeed proved the importance of miRNAs in cancer, suggesting their possible use as diagnostic, prognostic and predictive biomarkers and leading to exploit miRNA-based anticancer therapies, either alone or in combination with current targeted therapies, with the goal to improve disease response and increase cure rates.
Journal ArticleDOI
MicroRNA and cancer--a brief overview.
TL;DR: How miRNAs can be used as biomarkers and as a novel therapeutic approach in cancer is explained and the role of mi RNAs in cancer development and drug resistance is discussed.
Journal ArticleDOI
MicroRNA deregulation in human thyroid papillary carcinomas
Pierlorenzo Pallante,Rosa Visone,Rosa Visone,Manuela Ferracin,Angelo Ferraro,Mt Berlingieri,Giancarlo Troncone,Gennaro Chiappetta,Cg Liu,Massimo Santoro,Massimo Negrini,Carlo M. Croce,Alfredo Fusco +12 more
TL;DR: Analysis of genome-wide miRNA expression profile in human thyroid papillary carcinomas and functional studies suggest a critical role of miR-221 overexpression in thyroid carcinogenesis suggest miRNA deregulation as an important event in thyroid cell transformation.
PatentDOI
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
TL;DR: Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described in this article, which provide a useful animal model system for human B cell chronic lymphocytic leukemia.
Journal ArticleDOI
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
Ramiro Garzon,Michela Garofalo,Maria Paola Martelli,Roger Briesewitz,Lisheng Wang,Cecilia Fernandez-Cymering,Stefano Volinia,Chang Gong Liu,Susanne Schnittger,Torsten Haferlach,Arcangelo Liso,Daniela Diverio,Marco Mancini,Giovanna Meloni,Robin Foà,Massimo F. Martelli,Cristina Mecucci,Carlo M. Croce,Brunangelo Falini +18 more
TL;DR: A unique miRNA signature is identified that distinguishes NPMc+ mutated from the cytoplasmic-negative (NPM1 unmutated) cases and includes the up-regulation of miR-10a, miR -10b, several let-7 and miR –29 family members and support a role for miRNAs in the regulation of HOX genes in this leukemia subtype.