C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
Francesco Trapasso,Francesco Trapasso,Flavia Pichiorri,Marco Gaspari,Tiziana Palumbo,Tiziana Palumbo,Rami I. Aqeilan,Eugenio Gaudio,Eugenio Gaudio,Hiroshi Okumura,Rodolfo Iuliano,Rodolfo Iuliano,Giampiero Di Leva,Muller Fabbri,David E. Birk,Cinzia Raso,Kari B. Green-Church,Luigi Giusto Spagnoli,Salvatore Venuta,Kay Huebner,Carlo M. Croce +20 more
TL;DR: Characterization of Fhit interacting proteins has identified direct effectors of the Fhit-mediated apoptotic pathway that is lost in most cancers through loss of F hit.
Journal ArticleDOI
miR-15b/16-2 deletion promotes B-cell malignancies.
Francesca Lovat,Matteo Fassan,Matteo Fassan,Pierluigi Gasparini,Lara Rizzotto,Luciano Cascione,Marco Pizzi,Caterina Vicentini,Veronica Balatti,Dario Palmieri,Stefan Costinean,Carlo M. Croce +11 more
TL;DR: The results are the first, to the authors' knowledge, to suggest an important role of miR-15b/16-2 loss in the pathogenesis of B-cell chronic lymphocytic leukemia.
Journal ArticleDOI
Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas
Christine Schwienbacher,Laura Gramantieri,Rosaria Scelfo,Angelo Veronese,George A. Calin,Luigi Bolondi,Carlo M. Croce,Giuseppe Barbanti-Brodano,Massimo Negrini,Massimo Negrini +9 more
TL;DR: Loss of maternal-specific methylation at the KvDMR1 locus in hepatocarcinoma correlated with abnormal expression of CDKN1C and IGF2, suggesting a function for Kv DMR1 as a long-range imprinting center active in adult tissues.
Patent
Compositions and methods for cancer diagnosis and therapy
Carlo M. Croce,George A. Calin +1 more
TL;DR: The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer as mentioned in this paper.
Journal ArticleDOI
Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes.
Riccardo Dalla-Favera,Genoveffa Franchini,Stefano Martinotti,Flossie Wong-Staal,Robert C. Gallo,Carlo M. Croce +5 more
TL;DR: DNA from mouse-human somatic cell hybrids that have selectively lost human chromosomes was used in Southern blots to map the chromosomal location of two human onc genes to determine whether specific rearrangements involving these chromosomes result in the abnormal expression of these onc gene in human malignancies.