C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
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Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia
Amy J. Johnson,David M. Lucas,Natarajan Muthusamy,Lisa L. Smith,Ryan B. Edwards,Michael D. De Lay,Carlo M. Croce,Michael R. Grever,John C. Byrd +8 more
TL;DR: The TCL-1 transgenic leukemia mouse model has similar clinical and therapeutic response properties to human CLL and may therefore serve as a useful in vivo tool to screen new drugs for subsequent development in CLL.
Journal ArticleDOI
In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation
Flavia Pichiorri,Dario Palmieri,Luciana De Luca,Jessica Consiglio,Jia You,Alberto Rocci,Tiffany Talabere,Claudia Piovan,Alessandro Laganà,Luciano Cascione,Jingwen Guan,Pierluigi Gasparini,Veronica Balatti,Gerard J. Nuovo,Vincenzo Coppola,Craig C. Hofmeister,Guido Marcucci,John C. Byrd,Stefano Volinia,Charles L. Shapiro,Michael A. Freitas,Carlo M. Croce +21 more
TL;DR: The regulatory protein nucleolin controls the expression of a subset of miRNAs involved in breast cancer progression and can be targeted to inhibit breast cancer growth in vivo.
Journal ArticleDOI
MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer
Ri Cui,Ri Cui,Wei Meng,Hui-Lung Sun,Taewan Kim,Zhenqing Ye,Matteo Fassan,Young-Jun Jeon,Bin Li,Caterina Vicentini,Yong Peng,Yong Peng,Tae Jin Lee,Zhenghua Luo,Lan Liu,Dongyuan Xu,Esmerina Tili,Victor X. Jin,Justin Middleton,Arnab Chakravarti,Tim Lautenschlaeger,Carlo M. Croce +21 more
TL;DR: Up-regulated miR-224 facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC, and indicates that targeting miD-224 could be effective in the treatment of certain lung cancer patients.
Journal ArticleDOI
A Role for the WWOX Gene in Prostate Cancer
Haiyan R. Qin,Dimitrios Iliopoulos,Shuho Semba,Muller Fabbri,Teresa Druck,Stefano Volinia,Carlo M. Croce,Carl Morrison,Russell D. Klein,Kay Huebner +9 more
TL;DR: The data are consistent with a role for WWOX as a prostate cancer tumor suppressor and suggest that WWOX signal pathways should be further investigated in normal and cancerous prostate cells and tissues.
Journal ArticleDOI
WWOX in biological control and tumorigenesis.
Rami I. Aqeilan,Carlo M. Croce +1 more
TL;DR: It is demonstrated that targeted deletion of the Wwox gene in the mouse led to increased incidence of spontaneous and chemically induced tumor formation, thereby providing the first in vivo evidence that WWOX is a bona fide tumor suppressor.