University of Veterinary Science

About: University of Veterinary Science is a education organization based out in Pyinmana, Myanmar. It is known for research contribution in the topics: Population & Receptor. The organization has 597 authors who have published 650 publications receiving 14262 citations.

Glucocorticoid metabolism in testicular tissue: a key to fertility?

Abstract: Glucocorticoids are well-known as mediators of the systemic stress response. Increased glucocorticoid release and synthesis in response to endogenous or exogenous stressors have been shown to impair testicular hormone production in a variety of species and therefore may affect fertility. However, the physiological involvement of glucocorticoid hormones in tissue maturation and differentiation during both fetal and postnatal life is at least of similar importance as their role in the stress response. A well-regulated balance between beneficial and detrimental glucocorticoid hormone levels is therefore of utmost importance for tissue development as well as maintenance of tissue function. In the issue of the Asian Journal of Andrology, Zhou et al.1 have published a study investigating the involvement of 11β-hydroxysteroid dehydrogenase (11βHSD) types 1 and 2 in the maturation of rat testis. These isohormones catalyze the interconversion of active glucocorticoids and inert glucocorticoid metabolites at the cellular level. In their article, Zhou et al.1 are able not only to describe the expression pattern of the two isoforms during testicular development in the male rat. They also address the relevance of changes in the endocrine environment obtained by experimental manipulation of luteinizing hormone and testosterone concentrations on 11βHSD expression and testicular development. In addition, the use of immunohistochemistry allows describing cell-type related differentiation in enzyme expression and its response to the changes in hormone concentration. Not all results presented in this article are new, but it very nicely highlights the complexity of the 11βHSD system in the male gonad. Due to the fact that research with laboratory animals allows for collection of tissue samples in a high number of experimental animals and at a variety of maturational stages, a near-complete picture of changes in the expression of the 11βHSD system can be presented. This is extremely helpful for understanding the physiology and pathophysiology of testicular maturation – most probably not only in the male rat. Results obtained in laboratory animals can only in part be transformed to other mammalian species. However, the presence and relevance of the 11βHSD system in testicular tissue maturation has been demonstrated not only in laboratory rodent species2 but also in humans,3 some domestic animals (i.e., pigs4 and horses5) and in fish species. An involvement of these enzymes in testicular maturation and function in many other species thus appears feasible. The present results clearly underline the importance of fine tuning of glucocorticoid concentrations in male gonads for the development of fertility. Disturbance of these regulatory pathways may be a key factor to understanding of male infertility.

On the Occurrence of a New Transferrin Allele in Two Hungarian Cattle Breeds

Abstract: Some years ago Kristjansson (1962) and later Ashton (1965) and Jamieson (1965) succeded in subdividing the bovine transferrin D into D1 and D2 types by using various starch-gel electrophoretic techniques.

A Simple, Practical Method for Measurement of Fat in Milk, Applied to Mid- to Late-Lactating Working Elephants in Myanmar

Abstract: Determining nutrient composition of milk is not only of interest to dairy industry, but may play a key role improving maternal well-being and offspring health and survival in a range of species, including endangered populations of mammals managed in captivity. However, in field conditions, lack of transportation, reagents, equipment, and electricity may limit the applicability of methodologies developed for dairy livestock species to wildlife. One example of a population benefitting from a practical method to assess milk quality in the field is that of Asian elephants employed in timber industry in Myanmar. A third (~15,000) of the remaining, endangered population of Asian elephants lives in captivity in range countries [1]. The largest (~5000) such captive population is employed in the timber logging industry in Myanmar of which over half belong to the government-owned Myanma Timber Enterprise. However, high calf mortality poses a risk to the population viability: of the identified causes of calf mortality, malnutrition caused by agalactia (lack of or deficient milk production of mothers), was the death reason for 26.3% of calves dying before age 5 years [2]. Seasonal variation in climate, body condition and mortality rate may exacerbate such effects [3].