Open AccessJournal Article
Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary
Michael F. O'Rourke,Stanley S. Franklin,Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +11 more
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In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.Abstract:
In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.read more
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Cardiovascular disease in systemic sclerosis - an emerging association?
Gene-Siew Ngian,Gene-Siew Ngian,Joanne Sahhar,Ian P. Wicks,Ian P. Wicks,Sharon Van Doornum,Sharon Van Doornum +6 more
TL;DR: The literature describing cardiovascular disease in SSc is summarized, the pathophysiological mechanisms common to SSc and atherosclerosis are discussed, the surrogate markers of cardiovascular disease which have been examined are reviewed, and proposed mediators of the vasculopathy of SSc include endothelial dysfunction, a reduced number of circulating endothelial progenitor cells, and an increased number of microparticles.
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Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: A randomized, double-blind, placebo-controlled trial
Teppei Nakamura,Jun Mizutani,Kohji Ohki,Kazuhisa Yamada,Naoyuki Yamamoto,Masahiko Takeshi,Kenji Takazawa +6 more
TL;DR: Casein hydrolysate containing VPP and IPP improves central SBP and baPWV in hypertensive subjects, which suggests VPPand IPP might have beneficial effects on arterial properties.
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Sympathetic and vascular dysfunction in adult patients with Fontan circulation
Elisabeth Lambert,Elisabeth Lambert,Yves d'Udekem,Yves d'Udekem,Michael Cheung,Michael Cheung,Carolina I. Sari,Julia Inman,Anna A. Ahimastos,Nina Eikelis,Atul Pathak,Ingrid King,Ingrid King,Leeanne Grigg,Markus P. Schlaich,Markus P. Schlaich,Gavin W. Lambert,Gavin W. Lambert +17 more
TL;DR: Adult Fontan patients have increased MSNA and altered endothelial function that are likely to contribute to their known increased SVR andTherapies aiming at reducing the peripheral resistances should target endothelialfunction and sympathetic activity.
Journal ArticleDOI
Ambulatory recording of wave reflections and arterial stiffness during intra- and interdialytic periods in patients treated with dialysis.
Antonios Karpetas,Pantelis Sarafidis,Panagiotis I. Georgianos,Athanase D. Protogerou,Pantelis Vakianis,Georgios Koutroumpas,Vasileios Raptis,Dimitrios N. Stamatiadis,Christos Syrganis,Vassilios Liakopoulos,Georgios Efstratiadis,Anastasios N. Lasaridis +11 more
TL;DR: This study showed a gradual interdialytic increase in AIx, whereas PWV was only slightly elevated during Day 2, and future studies are needed to elucidate the value of these ambulatory measures for cardiovascular risk prediction in ESRD.
Journal ArticleDOI
Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population.
Otto Mayer,Jitka Seidlerová,Peter Wohlfahrt,Jan Filipovský,Jiří Vaněk,Renata Cifkova,Jindra Windrichova,Ondřej Topolčan,Marjo H. J. Knapen,Nadja E.A. Drummen,Cees Vermeer +10 more
TL;DR: Increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.
References
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Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
Stéphane Laurent,Pierre Boutouyrie,Roland Asmar,Isabelle Gautier,Brigitte Laloux,Louis Guize,Pierre Ducimetière,Athanase Benetos +7 more
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Björn Dahlöf,Peter S. Sever,Neil R Poulter,Hans Wedel,D Gareth Beevers,Mark J. Caulfield,Rory Collins,Sverre E. Kjeldsen,Arni Kristinsson,Gordon T. McInnes,Jesper Mehlsen,Markku S. Nieminen,Eoin O'Brien,Jan Östergren +13 more
TL;DR: The amlodipine-based regimen prevented more major cardiovascular events and induced less diabetes than the atenolol- based regimen, and these effects might not be entirely explained by better control of blood pressure.
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