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Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary

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TLDR
In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Abstract
In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.

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Reduced Ascending Aortic Strain and Distensibility: Earliest Manifestations of Vascular Aging in Humans

TL;DR: A dramatic decrease in AA distensibility is demonstrated before the fifth decade of life in individuals with diverse prevalence of risk factors free of overt cardiovascular disease, and compared with other measures of aortic function, the best markers of subclinical large artery stiffening were AAdistensibility in younger and aorti arch pulse wave velocity in older individuals.
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The aging kidney

TL;DR: This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in the understanding of the renal aging process.
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Arterial stiffness, atherosclerosis and cardiovascular risk: Pathophysiologic mechanisms and emerging clinical indications.

TL;DR: Arterial stiffness is emerging as an interesting tissue biomarker for cardiovascular risk stratification and estimation of the individual "biological age", and the evidence and caveat for clinical use of stiffness as surrogate marker of cardiovascular risk are summarized.
Journal ArticleDOI

Arterial stiffness and pulse pressure in CKD and ESRD

TL;DR: Premature vascular aging and arterial stiffening are observed with progression of chronic kidney disease and in end-stage renal disease and this accelerated aging is associated with outward remodeling of large vessels, characterized by increased arterial radius not totally compensated for by artery wall hypertrophy.
References
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Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.

TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
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