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Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary

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TLDR
In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Abstract
In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.

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Orthostatic hypotension in very old individuals living in nursing homes: the PARTAGE study

TL;DR: Contrary to the general belief, elderly individuals with well controlled BP (SBP < 140 mmHg) show lower orthostatic hypotension, thus constituting a complementary argument for efficaciously treating hypertension in these individuals.
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Adiposity, Obesity, and Arterial Aging Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort

TL;DR: The findings suggest that adiposity is an important and potentially modifiable determinant of arterial aging and general and central adiposity in later midlife were strong independent predictors of aortic stiffening.
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Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk.

TL;DR: Assessment of arterial stiffness is a sensitive and useful biomarker of cardiovascular risk because of its underlying pathophysiological mechanisms, and PWV is an emerging biomarker useful for reflecting risk stratification of patients and for assessing pharmacodynamic effects and efficacy in clinical studies.
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Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study.

TL;DR: It is suggested that brachial-ankle pulse wave velocity is a significant predictive factor for cardiovascular disease in the general Japanese population and that information on brachialspace wave velocity substantially improves cardiovascular risk assessment beyond that achieved by a model based on potential risk factors in general practice.
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Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study

TL;DR: High PWV is associated with a trend towards increasing CVD risk in both nonhypertensives and hypertensives, a finding that may support the use of arterial stiffness measurements in both populations.
References
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Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.

TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
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