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Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary

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TLDR
In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Abstract
In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.

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Journal ArticleDOI

Arterial stiffness, its assessment, prognostic value, and implications for treatment

TL;DR: Treatment options, which directly target the consequences of arterial stiffening, as opposed to arbitrary reduction of brachial blood pressure, have proved clinical superiority; optimal therapy entails use of angiotensin-converting enzyme inhibitors, angiotENSin-receptor blockers, and calcium-channel blockers, as well as vasodilating β-blockers.
Journal ArticleDOI

Amplification of the Pressure Pulse in the Upper Limb in Healthy, Middle-Aged Men and Women

TL;DR: It is concluded that, in healthy middle-aged subjects, the central-to-radial amplification of the pressure pulse is substantial, higher in men than in women, decreases with age, and is primarily associated with the carotid augmentation index.
Journal ArticleDOI

Arterial Stiffness and Wave Reflection: Biomarkers of Cardiovascular Risk.

Gary F. Mitchell
- 01 Jun 2009 - 
TL;DR: A dramatic increase in pulsatile energy content of pressure and flow waves in the arterial system places considerable pulsatile stress on the heart, large arteries and distal circulation.
Journal ArticleDOI

Arterial Pulse Wave Velocity and Cognition With Advancing Age

TL;DR: It is hypothesized that carotid-femoral pulse wave velocity interacts with age such that the magnitude of associations between PWV and cognitive performance are greater with increasing age and that this interaction is observed despite adjustments for demographic variables, mean arterial pressure, and cardiovascular risk factors.
References
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Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.

TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
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