Open AccessJournal Article
Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary
Michael F. O'Rourke,Stanley S. Franklin,Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +11 more
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In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.Abstract:
In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.read more
Citations
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Journal ArticleDOI
Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness
Journal ArticleDOI
Type 2 diabetes mellitus worsens arterial stiffness in hypertensive patients through endothelial dysfunction
Rosa Maria Bruno,Giuseppe Penno,Giuseppe Daniele,Laura Pucci,Daniela Lucchesi,Francesco Stea,Luigi Landini,G. Cartoni,Stefano Taddei,Lorenzo Ghiadoni,S. Del Prato +10 more
TL;DR: The results suggest that type 2 diabetes mellitus on top of hypertension might worsen arterial compliance by endothelium-related mechanisms, and endothelial dysfunction is a determinant of aortic stiffness in hypertensive diabetic patients but not in hypertension patients without diabetes.
Journal ArticleDOI
Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes
Kaire Heilman,Mihkel Zilmer,Kersti Zilmer,Mare Lintrop,Priit Kampus,Jaak Kals,Vallo Tillmann +6 more
TL;DR: Children with T1DM have substantially elevated plasma levels of myeloperoxidase as well as atherosclerosis-related structural and functional changes of the arterial wall.
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Non-invasive methods and techniques for central blood pressure estimation: procedures, validation, reproducibility and limitations.
Theodore G. Papaioannou,Athanassios D. Protogerou,Kimon Stamatelopoulos,Manolis Vavuranakis,Christodoulos Stefanadis +4 more
TL;DR: Methods and techniques that are used for the estimation of central blood pressures are presented and issues regarding methodological procedures, reproducibility, validity and limitations are described to describe and discuss.
Journal ArticleDOI
Effects of Low-Dose Atorvastatin on Arterial Stiffness and Central Aortic Pressure Augmentation in Patients With Hypertension and Hypercholesterolemia
Aggeliki I. Kanaki,Pantelis Sarafidis,Panagiotis I. Georgianos,Konstantinos Kanavos,I. Tziolas,Pantelis Zebekakis,Anastasios N. Lasaridis +6 more
TL;DR: This study shows that low-dose atorvastatin treatment improves arterial stiffness and exerts a reduction on central aortic pressures, which may represent a potential mechanism of cardiovascular risk reduction observed with statin use.
References
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Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
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Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
Stéphane Laurent,Pierre Boutouyrie,Roland Asmar,Isabelle Gautier,Brigitte Laloux,Louis Guize,Pierre Ducimetière,Athanase Benetos +7 more
TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
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Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial
Björn Dahlöf,Peter S. Sever,Neil R Poulter,Hans Wedel,D Gareth Beevers,Mark J. Caulfield,Rory Collins,Sverre E. Kjeldsen,Arni Kristinsson,Gordon T. McInnes,Jesper Mehlsen,Markku S. Nieminen,Eoin O'Brien,Jan Östergren +13 more
TL;DR: The amlodipine-based regimen prevented more major cardiovascular events and induced less diabetes than the atenolol- based regimen, and these effects might not be entirely explained by better control of blood pressure.
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