Genetic compensation: A phenomenon in search of mechanisms.
TLDR
This review revisits studies reporting genetic compensation in higher eukaryotes and outlines possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.Abstract:
Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target effects of the antisense reagents. An alternative explanation was recently proposed based on a zebrafish study reporting that genetic compensation was observed in egfl7 mutant but not knockdown animals. Dosage compensation was first reported in Drosophila in 1932, and genetic compensation in response to a gene knockout was first reported in yeast in 1969. Since then, genetic compensation has been documented many times in a number of model organisms; however, our understanding of the underlying molecular mechanisms remains limited. In this review, we revisit studies reporting genetic compensation in higher eukaryotes and outline possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.read more
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Proceedings ArticleDOI
627. Genetic prediction for growth traits in beef cattle using selected variants from imputed low-pass sequence data
TL;DR: In this article , the impact of variants identified from imputed lowpass sequence on the genetic prediction of birth weight (BWT) and post weaning gain (PWG) was assessed.
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Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis
Revenu des Courtils,Parlato,Parlato,Rosello,Duroure,Duclaux-Loras,Nicolle,Prosperi,Stoufflet,Stoufflet,Vougny,Lebreton,Lepine,Michaux,Cerf-Benssusan,Coudrier,Del Bene +16 more
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Preventing cancer by long-term partial Myc suppression
Nicole M. Sodir,Luca Pellegrinet,Roderik M. Kortlever,Yong-Won Kwon,Shinseog Kim,Daniel Garcia,Alessandra Perfetto,Panayiotis Anastasiou,Lamorna Brown Swigart,Trevor D. Littlewood,Gerard I. Evan +10 more
TL;DR: In this article, a genetically engineered mouse model was constructed in which Myc expression may be systemically and reversibly hypomorphed at will, and it was shown that Myc hypomorphism in adult mice conferred potent protection against both KRasG12D-driven lung and pancreatic cancers yet elicited only mild haematopoietic side effects.
Book ChapterDOI
Selective Inhibition of Kinase Activity in Mammalian Cells by Bioorthogonal Ligand Tethering.
TL;DR: In this article , a non-canonical amino acid bearing a bioorthogonal group is genetically incorporated into the target kinase by genetic code expansion, and the sensitized kinase can react with a conjugate containing a complementary biorthogonal groups linked with a known inhibitory ligand.
Posted ContentDOI
Eukaryotic translation initiation factor 5A and its hypusination play an important role in proliferation and differentiation of the human enteric protozoan parasite Entamoeba histolytica
Ghulam Jeelani,Tomoyoshi Nozaki +1 more
TL;DR: The results have underscored the essentiality of eIF5A and DHS, for proliferation and differentiation of this parasite, and suggest that the hypusination associated pathway represents a novel rational target for drug development against amebiasis.
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