Genetic compensation: A phenomenon in search of mechanisms.
TLDR
This review revisits studies reporting genetic compensation in higher eukaryotes and outlines possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.Abstract:
Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target effects of the antisense reagents. An alternative explanation was recently proposed based on a zebrafish study reporting that genetic compensation was observed in egfl7 mutant but not knockdown animals. Dosage compensation was first reported in Drosophila in 1932, and genetic compensation in response to a gene knockout was first reported in yeast in 1969. Since then, genetic compensation has been documented many times in a number of model organisms; however, our understanding of the underlying molecular mechanisms remains limited. In this review, we revisit studies reporting genetic compensation in higher eukaryotes and outline possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.read more
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Overexpression of the Chromosome Partitioning Gene parA in Azorhizobium caulinodans ORS571 Alters the Bacteroid Morphotype in Sesbania rostrata Stem Nodules.
TL;DR: It is proposed that the particular symbiosome formation in PnptII-parA stem-nodules is due to cell cycle disruption caused by excess ParA protein in the symbiotic cells during nodulation.
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SLC38A10 Knockout Mice Display a Decreased Body Weight and an Increased Risk-Taking Behavior in the Open Field Test
TL;DR: The results imply that a complete deficiency of the SLC38A10 protein might affect body weight homeostasis, but the underlying mechanisms needs to be studied further.
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Myeloid transformation by MLL-ENL depends strictly on C/EBP.
Radoslaw Wesolowski,Elisabeth Kowenz-Leutz,Karin Zimmermann,Dorothea Dörr,Maria Hofstätter,Robert K. Slany,Alexander Mildner,Achim Leutz +7 more
TL;DR: It is demonstrated that compound deletion of Cebpa/Cebpb almost entirely abrogated the growth and survival of MLL-ENL–transformed cells, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.
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Population Genetics Based Phylogenetics Under Stabilizing Selection for an Optimal Amino Acid Sequence: A Nested Modeling Approach
Jeremy M. Beaulieu,Brian C. O'Meara,Russell Zaretzki,Cedric Landerer,Juan juan Chai,Michael A. Gilchrist +5 more
TL;DR: A new phylogenetic approach SelAC (Selection on Amino acids and Codons), whose substitution rates are based on a nested model linking protein expression to population genetics, indicates there is great potential for more accurate inference of phylogenetic trees and branch lengths from already existing data through the use of nested, mechanistic models.
Posted ContentDOI
Hmx3a has essential functions in zebrafish spinal cord, ear and lateral line development
Samantha J. England,Gustavo A. Cerda,Angelica M Kowalchuk,Taylor Sorice,Ginny Grieb,Katharine E. Lewis +5 more
TL;DR: Using mutational analyses, it is demonstrated that, in addition to its previously reported role in ear development, hmx3a is required for correct specification of a subset of spinal interneuron neurotransmitter phenotypes, as well as correct lateral line progression and survival to adulthood.
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