Genetic compensation: A phenomenon in search of mechanisms.
TLDR
This review revisits studies reporting genetic compensation in higher eukaryotes and outlines possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.Abstract:
Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target effects of the antisense reagents. An alternative explanation was recently proposed based on a zebrafish study reporting that genetic compensation was observed in egfl7 mutant but not knockdown animals. Dosage compensation was first reported in Drosophila in 1932, and genetic compensation in response to a gene knockout was first reported in yeast in 1969. Since then, genetic compensation has been documented many times in a number of model organisms; however, our understanding of the underlying molecular mechanisms remains limited. In this review, we revisit studies reporting genetic compensation in higher eukaryotes and outline possible molecular mechanisms, which may include both transcriptional and posttranscriptional processes.read more
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Animal Models of Autosomal Recessive Parkinsonism.
Guendalina Bastioli,Maria Regoni,Federico Angelo Cazzaniga,Chiara De Luca,Edoardo Bistaffa,Letizia Zanetti,Fabio Moda,Flavia Valtorta,Jenny Sassone +8 more
TL;DR: Parkinson's disease (PD) is the most common neurodegenerative movement disorder and the neuropathological hallmark of the disease is the loss of dopamine neurons of the substantia nigra pars compacta as discussed by the authors.
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Deconstructing the molecular genetics behind the PINK1/Parkin axis in Parkinson’s disease using Drosophila melanogaster as a model organism
TL;DR: In this paper, a review aims to probe the current understanding of PD pathogenesis via the PINK1/Parkin axis while underscoring the importance of several molecular and pharmacologic rescues brought to light through studies in Drosophila.
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Molecular characterisation of the GdhA- derivative of Pasteurella multocida B:2
Farahani Muhammad Azam,Mohd Zamri-Saad,Raha Abdul Rahim,Pramote Chumnanpuen,Teerasak E-kobon,Sarah Othman +5 more
TL;DR: A reproducible PCR detection method has enabled differentiation of both strains ofasteurella multocida B:2 GDH7 and the virulent parent strain, showing a significantly different profile through genomic and proteomic profiling.
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Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
Atsuhiro Tsutiya,Mitsumi Arito,Takuma Tagashira,Masaaki Sato,Kazuki Omoteyama,Toshiyuki Sato,Naoya Suematsu,Manae S. Kurokawa,Tomohiro Kato +8 more
TL;DR: In this paper, the authors investigated precise intracellular localization of layilin and the location-related functions, and found that layin localized to mitochondria rather than the other organelles.
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Compensatory Upregulation of LPA2 and Activation of the PI3K-Akt Pathway Prevent LPA5-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids
Zhongxing Liang,C. Chris Yun +1 more
TL;DR: Evidence is provided that loss of an LPAR can be compensated by another LPAR, which needs to be considered in studies aimed to define receptor functions or test the efficacy of a LPAR-targeting drug using genetically engineered animal models.
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