Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Journal ArticleDOI
Genetics of hypertension.
Paul N. Hopkins,Steven C. Hunt +1 more
TL;DR: This work has shown that the carotid and intracerebral vascular beds are relatively protected from atherosclerosis as compared to the coronary circulation, particularly at lower blood pressures, and that higher sheer stress is a strong stimulus for release of nitric oxide that locally decreases risk of Atherosclerosis.
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Perianeurysmal Brain Inflammation after Flow-Diversion Treatment
TL;DR: It is found that MR imaging−defined perianeurysmal inflammation is observed with a high frequency after treatment of unruptured aneurysms with flow diverters and is, in most cases, associated with a transient clinical deterioration.
Journal ArticleDOI
OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries
Kenichi Fujii,Daizo Kawasaki,Motomaru Masutani,Takahiro Okumura,Takafumi Akagami,Tsuyoshi Sakoda,Takeshi Tsujino,Mitsumasa Ohyanagi,Tohru Masuyama +8 more
TL;DR: Three-vessel OCT imaging showed that TCFAs tend to cluster in predictable spots within the proximal segment of the LAD, but develop relatively evenly in the LCx and RCA arteries.
Journal ArticleDOI
Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy.
Pim van Ooij,Wouter V. Potters,Jeremy D. Collins,Maria Carr,James C. Carr,S. Chris Malaisrie,Paul W.M. Fedak,Patrick M. McCarthy,Michael Markl,Alex J. Barker +9 more
TL;DR: A novel approach to characterize regional aortic WSS may allow clinicians to gain unique insights regarding the heterogeneous expression of aortopathy and may be leveraged to guide patient-specific resection strategies for aorta repair.
Journal ArticleDOI
Investigation of Pulsatile Flowfield in Healthy Thoracic Aorta Models
TL;DR: The numerical results suggest that the effects of low WSS and high OSI tend to cause wall thickening occurred along the inferior wall of the aortic arch and the anterior wall ofThe brachiocephalic artery, similar implication reported in a number of previous studies.
References
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Journal ArticleDOI
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