Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Journal ArticleDOI
Association of Coronary Wall Shear Stress With Atherosclerotic Plaque Burden, Composition, and Distribution in Patients With Coronary Artery Disease
Parham Eshtehardi,Michael C. McDaniel,Jin Suo,Saurabh S. Dhawan,Lucas H. Timmins,Lucas H. Timmins,Jose N. Binongo,Lucas Golub,Michel T. Corban,Aloke V. Finn,John N. Oshinski,Arshed A. Quyyumi,Don P. Giddens,Habib Samady +13 more
TL;DR: In patients with coronary artery disease, low WSS is associated with plaque necrotic core and calcium, independent of plaque burden, which suggests a link between WSS and coronary plaque phenotype.
Journal ArticleDOI
Global Analysis of Shear Stress-Responsive Genes in Vascular Endothelial Cells
Norihiko Ohura,Kimiko Yamamoto,S Ichioka,Takaaki Sokabe,H Nakatsuka,Atsushi Baba,Masahiro Shibata,Takashi Nakatsuka,Kiyonori Harii,Youichiro Wada,Takahide Kohro,Tatsuhiko Kodama,Joji Ando +12 more
TL;DR: Turbulent shear stress affected expression of many genes that play a role in vascular remodeling, including genes encoding plasminogen activators and their inhibitor, endothelin-1, transforming growth factor-beta, collagen type IV, and ephrin A1.
Journal ArticleDOI
Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications
Frank J. H. Gijsen,Yuki Katagiri,Peter Barlis,Peter Barlis,Christos V. Bourantas,Christos V. Bourantas,Carlos Collet,Umit Coskun,Joost Daemen,Jouke Dijkstra,Elazer R. Edelman,Elazer R. Edelman,Paul C. Evans,Kim Van der Heiden,Rod Hose,Rod Hose,Bon Kwon Koo,Bon Kwon Koo,Rob Krams,Alison L. Marsden,Francesco Migliavacca,Yoshinobu Onuma,Andrew Ooi,Eric K. W. Poon,Habib Samady,Peter Stone,Kuniaki Takahashi,Dalin Tang,Vikas Thondapu,Vikas Thondapu,Erhan Tenekecioglu,Lucas H. Timmins,Lucas H. Timmins,Ryo Torii,Jolanda J. Wentzel,Patrick W. Serruys,Patrick W. Serruys,Patrick W. Serruys +37 more
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
Journal ArticleDOI
Intravascular Ultrasound Classification of Plaque Distribution in Left Main Coronary Artery Bifurcations Where Is the Plaque Really Located
Carlos Oviedo,Akiko Maehara,Gary S. Mintz,Hiroshi Araki,So-Yeon Choi,Kenichi Tsujita,Takashi Kubo,Hiroshi Doi,Barry Templin,Alexandra J. Lansky,George Dangas,Martin B. Leon,Roxana Mehran,Seung-Jea Tahk,Gregg W. Stone,Masahiko Ochiai,Jeffrey W. Moses +16 more
TL;DR: In this paper, the authors reviewed 140 angiograms of distal left main coronary artery (LMCA) and ostial left anterior descending (LAD) and left circumflex (LCX) artery lesions with preintervention intravascular ultrasound (IVUS) of both the LAD and LCX arteries as well as the LMCA.
Journal ArticleDOI
Hemodynamic Shear Stress via ROS Modulates PCSK9 Expression in Human Vascular Endothelial and Smooth Muscle Cells and Along the Mouse Aorta
Zufeng Ding,Shijie Liu,Xianwei Wang,Xiaoyan Deng,Yubo Fan,Changqing Sun,Yannian Wang,Jawahar L. Mehta +7 more
TL;DR: Evidence is provided that low shear stress enhances PCSK9 expression in concert with ROS generation in vascular ECs and SMCs, and it is proposed thatPCSK9-ROS interaction may be important in the development of atherosclerosis in arterial channels with lowShear stress.
References
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Atherosclerosis — An Inflammatory Disease
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