Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Patient-specific computational haemodynamics: generation of structured and conformal hexahedral meshes from triangulated surfaces of vascular bifurcations.
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Method and system for image processing to determine patient-specific blood flow characteristics
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Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets
Yanfang Pan,Yanfang Pan,Yanfang Pan,Tadayuki Yago,Jianxin Fu,Jianxin Fu,Brett H. Herzog,Brett H. Herzog,J. Michael McDaniel,Padmaja Mehta-D’souza,Xiaofeng Cai,Changgeng Ruan,Rodger P. McEver,Rodger P. McEver,Christopher M. West,Kesheng Dai,Hong Chen,Hong Chen,Lijun Xia,Lijun Xia,Lijun Xia +20 more
TL;DR: It is reported that core 1 O-glycan-deficient or desialylated PDPN was highly susceptible to proteolytic degradation by various proteases, including metalloproteinases (MMP)-2/9 and GM6001 treatment rescued the reduction of P DPN level on lymphatic endothelial cells in mice lacking endothelial core 2 O- glycan or cecal ligation and puncture-treated mice.
Journal ArticleDOI
Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration
Lisong Ai,Mahsa Rouhanizadeh,Joseph C. Wu,Wakako Takabe,Hongyu Yu,Mohammad Alavi,Rongsong Li,Yi Chu,Jordan D. Miller,Donald D. Heistad,Tzung K. Hsiai +10 more
TL;DR: It is demonstrated that shear stress in the atheroprone versus atheroprotective regions regulates spatial variations in mitochondrial Mn-SOD expression with an implication for modulating LDL nitration.
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Optical coherence tomography angiography and photoacoustic imaging in dermatology
Mengyang Liu,Wolfgang Drexler +1 more
TL;DR: The most updated results of skin disease imaging using these two optical imaging modalities are described, with emphasis on dual modality imaging combining OCTA and photoacoustic tomography (PAT) for dermatological applications.
References
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Journal ArticleDOI
The pathogenesis of coronary artery disease and the acute coronary syndromes (1).
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