Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Journal ArticleDOI
Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo
Alexandra C. Rinkenauer,Adrian T. Press,Martin Raasch,Christian Pietsch,Simon Schweizer,Simon Schwörer,Karl Lenhard Rudolph,Alexander S. Mosig,Michael Bauer,Anja Traeger,Ulrich S. Schubert +10 more
TL;DR: Physiological conditions such as cell-cell communication of co-cultured endothelial cells and macrophages as well as mechanotransductive signaling through shear stress significantly alter cellular nanoparticle uptake.
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High shear stress induces a strain increase in human coronary plaques over a 6-month period.
Frank J. H. Gijsen,Frits Mastik,Johannes A. Schaar,Johan C.H. Schuurbiers,Wim J. van der Giessen,Pim J. de Feyter,Patrick W. Serruys,Anton F. W. van der Steen,Jolanda J. Wentzel +8 more
TL;DR: It is observed that those plaque regions exposed to high shear stress showed an increase in strain over time, which indicates that shear Stress may modulate plaque composition in human coronary arteries.
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A Disposable Microfluidic Device for Controlled Drug Release from Thermal-Sensitive Liposomes by High Intensity Focused Ultrasound
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Prediction of the level and duration of shear stress exposure that induces subhemolytic damage to erythrocytes.
TL;DR: A model that may be used to predict whether RBC deformability is decreased following exposure to a given level and duration of SS is provided, and may guide design of future generations of mechanical circulatory assist devices.
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Wall shear stresses remain elevated in mature arteriovenous fistulas: a case study.
TL;DR: It is theorized that the vessel remodelling and the continued non-physiological hemodynamics within the AVF compound to result in stenotic lesion development.
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