Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Retrograde Blood Flow in the Aortic Arch Determined by Transesophageal Doppler Ultrasound
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Journal ArticleDOI
Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing.
Hassan Chami,Michelle J. Keyes,Joseph A. Vita,Gary F. Mitchell,Martin G. Larson,Shuxia Fan,Ramachandran S. Vasan,George T. O'Connor,Emelia J. Benjamin,Daniel J. Gottlieb +9 more
TL;DR: A moderate association of SDB and larger baseline brachial artery diameter is supported, which may reflect SDB-induced vascular remodeling and reflect the effect of sleep-disordered breathing on arterial diameter and peripheral blood flow.
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Risk of Coronary and Other Nonstroke Vascular Death in Relation to the Presence and Extent of Atherosclerotic Disease at the Carotid Bifurcation
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The effects of time varying curvature on species transport in coronary arteries.
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Absorbable magnesium-based stent: physiological factors to consider for in vitro degradation assessments
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References
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Journal ArticleDOI
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