Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Differential gene expression by endothelial cells under positive and negative streamwise gradients of high wall shear stress.
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F-Actin–Anchored Focal Adhesions Distinguish Endothelial Phenotypes of Human Arteries and Veins
Daphne van Geemen,Michel W.J. Smeets,Anne Marieke D. Van Stalborch,Leonie A. E. Woerdeman,Mat J.A.P. Daemen,Peter L. Hordijk,Stephan Huveneers +6 more
TL;DR: The data show that F-actin–anchored focal adhesions distinguish endothelial phenotypes of human arteries from veins, and conclude that the biomechanical properties of the vascular extracellular matrix determine this endothelial characteristic.
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Microfabrication of cylindrical microfluidic channel networks for microvascular research
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Endothelial Cell Mechanotransduction in the Dynamic Vascular Environment.
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References
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