Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Three-dimensional registration of histology of human atherosclerotic carotid plaques to in-vivo imaging.
Harald C. Groen,Theo van Walsum,S. Rozie,Stefan Klein,Kim van Gaalen,Frank J. H. Gijsen,Piotr A. Wielopolski,Heleen M.M. van Beusekom,Rini de Crom,Hence J.M. Verhagen,Antonius F.W. van der Steen,Aad van der Lugt,Jolanda J. Wentzel,Wiro J. Niessen +13 more
TL;DR: A fully three-dimensional approach for this registration problem, which accounts for deformations that occur during the processing of the specimens, and a new 3D-reconstruction technique of atherosclerotic plaque tissue opens new avenues in the field of biomechanics.
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References
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