Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
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TLDR
The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.Abstract:
Atherosclerosis, the leading cause of death in the developed world and
nearly the leading cause in the developing world, is associated with systemic
risk factors including hypertension, smoking, hyperlipidemia, and diabetes
mellitus, among others. Nonetheless, atherosclerosis remains a geometrically
focal disease, preferentially affecting the outer edges of vessel bifurcations.
In these predisposed areas, hemodynamic shear stress, the frictional force
acting on the endothelial cell surface as a result of blood flow, is weaker
than in protected regions. Studies have identified hemodynamic shear stress
as an important determinant of endothelial function and phenotype. Arterial-level
shear stress (>15 dyne/cm2) induces endothelial quiescence and
an atheroprotective gene expression profile, while low shear stress (<4
dyne/cm2), which is prevalent at atherosclerosis-prone sites, stimulates
an atherogenic phenotype. The functional regulation of the endothelium by
local hemodynamic shear stress provides a model for understanding the focal
propensity of atherosclerosis in the setting of systemic factors and may help
guide future therapeutic strategies.read more
Citations
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Journal ArticleDOI
Mechanistic insight into the physiological relevance of helical blood flow in the human aorta: an in vivo study
Umberto Morbiducci,Raffaele Ponzini,Giovanna Rizzo,Marcello Cadioli,Antonio Esposito,Franco Maria Montevecchi,Alberto Redaelli +6 more
TL;DR: The hemodynamics within the aorta of five healthy humans were investigated and group analysis suggested that aortic helical blood flow dynamics is an emerging behavior that is common to normal individuals, and the results suggest that helical flow might be caused by natural optimization of fluid transport processes in the cardiovascular system.
Book
Red Blood Cell Aggregation
TL;DR: Red blood cell aggregation / , Red blood cell aggregates / , کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
Patient-Specific Multiscale Modeling of Blood Flow for Coronary Artery Bypass Graft Surgery
Sethuraman Sankaran,Mahdi Esmaily Moghadam,Andrew M. Kahn,Elaine E. Tseng,Julius M. Guccione,Alison L. Marsden +5 more
TL;DR: A computational framework for multiscale modeling and simulation of blood flow in coronary artery bypass graft (CABG) patients is presented and it is observed that PV loops do not change significantly after CABG but that both coronary perfusion and local hemodynamic parameters near the anastomosis region change substantially.
Journal ArticleDOI
Finite element simulation of blood flow in the cerebral artery
TL;DR: In this paper, the authors developed a numerical simulation system for the clinical study of a cerebral aneurysm, which consists of three processes: pre-processing, numerical simulation and post-processing.
Journal ArticleDOI
Strain distribution over plaques in human coronary arteries relates to shear stress.
Frank J. H. Gijsen,Jolanda J. Wentzel,Attila Thury,Frits Mastik,Johannes A. Schaar,Johan C.H. Schuurbiers,Cornelis J. Slager,Wim J. van der Giessen,Pim J. de Feyter,Anton F. W. van der Steen,Patrick W. Serruys +10 more
TL;DR: High shear stress might destabilize plaques, which could lead to plaque rupture, and higher strain can be found in all other plaque regions, with the highest strain found in regions exposed to the highest shear stresses.
References
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